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In the US, Evolocumab (evolocumab systemic) is a member of the drug class PCSK9 inhibitors and is used to treat Cardiovascular Risk Reduction, High Cholesterol, High Cholesterol - Familial Heterozygous and High Cholesterol - Familial Homozygous.

US matches:



ATC (Anatomical Therapeutic Chemical Classification)


CAS registry number (Chemical Abstracts Service)


Chemical Formula


Molecular Weight


Therapeutic Categories

Lipid lowering agent for the treatment of homozygous familial hypercholesterolemia

Lipid modifying agent

Chemical Name

Immunoglobulin G2-lambda, anti-[Homo sapiensPCSK9 (proprotein convertase subtilisin/kexin type 9)], Homo sapiensmonoclonal antibody;gamma2 haevy chain (1-441)[Homo sapiensVH (IGHV1-18*01 (93.90%) -(IGHD)-IGHJ6*01))[8.8.8](1-115) -IGHG2*01 (CH1 (116-213), hinge (214-225), CH2 (226-334), CH3 (335-439), CHS (440-441))(116-441)], (129-214')-disulfide with lambda light chain (1'-215')[Homo sapiensV-LAMBDA (IGLV2-14*01 (95.90%) -IGLJ2*01)[9.3.9](1'-109') -IGLC2*01 (110'-2015')]; dimer (217-217''.218-218''.221-221''.224-224'')-tetrakisdisulfide (WHO)

Foreign Names

  • Evolocumabum (Latin)
  • Evolocumab (German)
  • √Čvolocumab (French)
  • Evolocumab (Spanish)

Generic Names

Brand Names

  • Repatha
    Amgen, Australia; Amgen, Bosnia & Herzegowina; Amgen, Belgium; Amgen, Canada; Amgen, Czech Republic; Amgen, Denmark; Amgen, Estonia; Amgen, Spain; Amgen, Finland; Amgen, United Kingdom; Amgen, Lithuania; Amgen, Latvia; Amgen, Norway; Amgen, Russian Federation; Amgen, Sweden; Amgen, Slovakia; Amgen, Turkey; Amgen, United States; Amgen Astellas BioPharma, Japan; Amgen Biotecnologia do Brasil, Brazil; Amgen Europe, Netherlands; Amgen Europe, Romania; Amgen Europe B.V., Israel; Amgen Europe BV, Greece; Amgen Europe BV, Iceland; Amgen Ltd., Ireland
  • Repatha 140mg
    Amgen, Germany; Amgen, Hungary; Amgen, Luxembourg; Amgen Europe, Austria
  • Repatha 420mg
    Amgen, Germany


ISInofficial Synonym
JANJapanese Accepted Name
OSOfficial Synonym
Rec.INNRecommended International Nonproprietary Name (World Health Organization)
USANUnited States Adopted Name
WHOWorld Health Organization

Further information on drug naming conventions: International Nonproprietary Names.

Important Notice: The international database is in BETA release. This means it is still under development and may contain inaccuracies. It is not intended as a substitute for the expertise and judgement of your physician, pharmacist or other healthcare professional. It should not be construed to indicate that the use of any medication in any country is safe, appropriate or effective for you. Consult with your healthcare professional before taking any medication.

Further information

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