Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- Compound 374 (enflurane)
- deserpidine
Interactions between your drugs
enflurane deserpidine
Applies to: Compound 374 (enflurane), deserpidine
MONITOR: Rauwolfia alkaloids may accentuate the hypotensive effects of general anesthetics by depleting catecholamine neurotransmitters. Data are conflicting and are available for rauwolfia and reserpine only.
MANAGEMENT: Patients should be closely monitored. If profound hypotension occurs, a direct-acting sympathomimetic agent, such as dobutamine or epinephrine, may be required.
References (2)
- Ziegler CH, Lovette JB (1961) "Operative complications after therapy with reserpine and reserpine compounds." JAMA, 176, p. 114-7
- Jahr JS, Weber S (1991) "Ventricular dysrhythmias following an alfentanil anesthetic in a patient on reserpine for hypertension." Acta Anaesthesiol Scand, 35, p. 788-9
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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