Drug Interaction Report

Using rivaroxaban together with dipyridamole may increase the risk of bleeding, including severe and sometimes fatal hemorrhage. Talk to your doctor if you have any questions or concerns. Your doctor may already be aware of the risks, but has determined that this is the best course of treatment for you and has taken appropriate precautions and is monitoring you closely for any potential complications. You should seek immediate medical attention if you experience any unusual bleeding or bruising, or have other signs and symptoms of bleeding such as dizziness; lightheadedness; red or black, tarry stools; coughing up or vomiting fresh or dried blood that looks like coffee grounds; severe headache; and weakness. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Caffeine may interfere with the effects of dipyridamole in dilating the arteries. You should avoid caffeine-containing products for at least 24 hours before an imaging procedure involving dipyridamole given by injection. However, no special precaution is necessary if you are taking dipyridamole orally for maintenance.

Ask your doctor before using dipyridamole together with caffeine. Using these medications together can decrease the effects of dipyridamole. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before dipyridamole administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.