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Drug Interaction Report

2 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Major

dexAMETHasone elacestrant

Applies to: Dalalone (dexamethasone), elacestrant

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration with potent or moderate inducers of CYP450 3A4 may significantly decrease the plasma concentrations of elacestrant, which is primarily metabolized by the isoenzyme. When elacestrant (345 mg single dose) was administered with rifampin, a potent CYP450 3A4 inducer, elacestrant peak plasma concentration (Cmax) and systemic exposure (AUC) decreased by 73% and 86%, respectively. Concomitant use of efavirenz, a moderate CYP450 3A4 inducer, is predicted to decrease elacestrant (345 mg single dose) Cmax and AUC by 44% to 63% and 55% to 73%, respectively. Reduced effectiveness of elacestrant may result.

MANAGEMENT: Coadministration of elacestrant and potent or moderate CYP450 3A4 inducers should be generally avoided. However, some authorities recommend continuing elacestrant without dose adjustment if a strong or moderate CYP450 3A4 inducer must be used for a short duration of time (i.e. less than or equal to 3 days) or intermittently (i.e. treatment periods less than or equal to 3 days separated by at least 2 weeks or 1 week and 5 half-lives of the CYP450 3A4 inducer, whichever is longer).

Drug and food interactions

Major

elacestrant food

Applies to: elacestrant

Elacestrant should be taken with food at approximately the same time each day. Grapefruit, grapefruit juice, and supplements that contain grapefruit, however, may increase the blood levels of elacestrant, which may increase the risk of side effects such as muscle pain, nausea, increased cholesterol, increased liver enzymes, fatigue, decreased hemoglobin, and vomiting. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.