Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- vadadustat
- tovorafenib
Interactions between your drugs
vadadustat tovorafenib
Applies to: vadadustat, tovorafenib
MONITOR: Coadministration with inhibitors of CYP450 2C8 may increase the plasma concentrations and effects of tovorafenib, which has been found in vitro to be primarily metabolized by CYP450 2C8 and aldehyde oxidase, and to a lesser extent, by the isoenzymes CYP450 3A, 2C9, and 2C19. Increased plasma concentrations may increase the risk for adverse drug reactions including but not limited to, hemorrhage, skin toxicity, photosensitivity, hepatotoxicity, and reduced growth velocity in patients 18 years of age or younger. However, data from formal clinical drug interaction studies are not available.
MANAGEMENT: Caution is advised if tovorafenib is prescribed in combination with CYP450 2C8 inhibitors. Patients should be monitored for the development of hemorrhage, skin toxicity, photosensitivity, hepatotoxicity, and, in patients 18 years of age or younger, reduced growth velocity. Alternative therapy may need to be considered if a drug interaction is suspected.
References (1)
- (2024) "Product Information. Ojemda (tovorafenib)." Day One Biopharmaceuticals, Inc.
Drug and food interactions
vadadustat food
Applies to: vadadustat
MONITOR: Smoking and alcohol consumption during therapy with vadadustat may increase the risk of gastrointestinal erosions. Serious erosions, including gastrointestinal bleeding and the need for red blood cell transfusions, have been reported during vadadustat clinical trials. Patients with a history of gastrointestinal erosion, peptic ulcer disease, and current tobacco smokers and alcohol drinkers may be at higher risk of gastrointestinal injury.
MANAGEMENT: Caution is advised if vadadustat is prescribed to current tobacco smokers or alcohol drinkers. Patients should be advised to contact their physician if they develop potential signs and symptoms of gastrointestinal injury such as abdominal pain, hematemesis, trouble swallowing, chest or throat pain, and/or black, tarry stools.
References (3)
- (2023) "Product Information. Vafseo (vadadustat)." Adjutor Healthcare Pty Ltd
- (2024) "Product Information. Vafseo (vadadustat)." Akebia Therapeutics
- (2024) "Product Information. Vafseo (vadadustat)." Medice UK Ltd
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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