Drug Interaction Report

Simeprevir may increase the blood levels and effects of momelotinib. You may need a dose adjustment or more frequent monitoring by your doctor to safely use both medications. Contact your doctor if your condition changes or you experience increased side effects such as fever, chills, cough, chest pain, shortness of breath (with or without chest discomfort), diarrhea, dizziness, fatigue, pain, redness or swelling in an extremity, nausea or vomiting, unusual bruising or bleeding, dark urine, or pain on the right side of the abdomen. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Food significantly increases the absorption of simeprevir. You should take each dose of simeprevir with food. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication.