Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- pafolacianine
- Restora Rx (folic acid / lactobacillus casei)
Interactions between your drugs
folic acid pafolacianine
Applies to: Restora Rx (folic acid / lactobacillus casei), pafolacianine
ADJUST DOSING INTERVAL: Concomitant administration of folate, folic acid, or folate-containing supplements may reduce the binding of pafolacianine to folate receptors overexpressed on ovarian cancer cells. This may lead to a reduction in the detection of malignant lesions with pafolacianine.
MANAGEMENT: Concomitant use of folate, folic acid, or folate-containing supplements with pafolacianine is not recommended. The manufacturer advises that these supplements should be discontinued 48 hours before the administration of pafolacianine.
References (1)
- (2021) "Product Information. Cytalux (pafolacianine)." Grand River Aseptic Manufacturing
Drug and food/lifestyle interactions
folic acid food/lifestyle
Applies to: Restora Rx (folic acid / lactobacillus casei)
MONITOR: Ethanol may increase folic acid elimination and folic acid absorption is decreased in chronic alcoholics. Excessive alcohol consumption may lead to folate deficiency.
MANAGEMENT: Monitoring of patient response to folic acid supplementation if they also consume alcohol regularly may be recommended.
References (5)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- Agencia Española de Medicamentos y Productos Sanitarios Healthcare (2008) Centro de información online de medicamentos de la AEMPS - CIMA. https://cima.aemps.es/cima/publico/home.html
- Cerner Multum, Inc (2015) "ANVISA Bulário Eletrônico."
- (2017) "Product Information. Folic Acid (folic acid)." Method Pharmaceuticals, LLC
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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