Drug Interaction Report
9 potential interactions and/or warnings found for the following 2 drugs:
- adenosine / lidocaine / magnesium sulfate
- betamethasone / iodixanol / lidocaine
Interactions between your drugs
magnesium sulfate betamethasone
Applies to: adenosine / lidocaine / magnesium sulfate, betamethasone / iodixanol / lidocaine
Talk to your doctor before using betamethasone together with any kind of medication that has a laxative effect. Combining these medications, especially over a prolonged period, may increase the risk of dehydration and hypokalemia, or low blood potassium. In severe cases, hypokalemia can lead to muscle weakness, paralysis, breathing and swallowing difficulties (due to muscle paralysis), and irregular heart rhythm. Contact your doctor if you experience nausea, vomiting, dry mouth, thirst, decreased urination, constipation, abdominal cramping, confusion, dizziness, lightheadedness, fainting, muscle weakness, muscle cramps, numbness or tingling, rapid heart beat, chest pain, and/or swelling in the legs or feet, as these may be symptoms of dehydration and hypokalemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Drug and food interactions
lidocaine food
Applies to: adenosine / lidocaine / magnesium sulfate, betamethasone / iodixanol / lidocaine
Grapefruit juice may increase the blood levels of lidocaine, which may increase the risk of side effects such as low blood pressure, slow heart rate, irregular heart rhythm, difficulty breathing and convulsions. Cigarette smoking may reduce the blood levels of lidocaine, which may make the medication less effective. It is best to avoid smoking during lidocaine therapy. Consuming cruciferous vegetables (e.G., broccoli, brussels sprouts) may also reduce the blood levels of lidocaine. Talk to a healthcare professional if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
adenosine food
Applies to: adenosine / lidocaine / magnesium sulfate
Adenosine is used for heart imaging in the hospital or clinic setting. Caffeine should be avoided for 12 to 24 hours before adenosine administration. Avoid drinks, foods, or diet pills that contain caffeine, such as coffee, tea, cola, and chocolate. Taking a stimulant together with adenosine can increase your risk of unpleasant side effects.
adenosine food
Applies to: adenosine / lidocaine / magnesium sulfate
Ask your doctor before using adenosine together with caffeine. Using these medications together can decrease the effects of adenosine. It is recommended that caffeine including caffeine be avoided for 12 to 24 hours before adenosine administration. You may need a dose adjustment or special test if you use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
lidocaine food
Applies to: adenosine / lidocaine / magnesium sulfate, betamethasone / iodixanol / lidocaine
Consumer information for this interaction is not currently available.
MONITOR: Smoking cessation may lead to elevated plasma concentrations and enhanced pharmacologic effects of drugs that are substrates of CYP450 1A2 (and possibly CYP450 1A1) and/or certain drugs with a narrow therapeutic index (e.g., flecainide, pentazocine). One proposed mechanism is related to the loss of CYP450 1A2 and 1A1 induction by polycyclic aromatic hydrocarbons in tobacco smoke; when smoking cessation agents are initiated and smoking stops, the metabolism of certain drugs may decrease leading to increased plasma concentrations. The mechanism by which smoking cessation affects narrow therapeutic index drugs that are not known substrates of CYP450 1A2 or 1A1 is unknown. The clinical significance of this interaction is unknown as clinical data are lacking.
MANAGEMENT: Until more information is available, caution is advisable if smoking cessation agents are used concomitantly with drugs that are substrates of CYP450 1A2 or 1A1 and/or those with a narrow therapeutic range. Patients receiving smoking cessation agents may require periodic dose adjustments and closer clinical and laboratory monitoring of medications that are substrates of CYP450 1A2 or 1A1.
adenosine food
Applies to: adenosine / lidocaine / magnesium sulfate
Information for this minor interaction is available on the professional version.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Antiarrhythmics
Therapeutic duplication
The recommended maximum number of medicines in the 'antiarrhythmics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antiarrhythmics' category:
- adenosine / lidocaine / magnesium sulfate
- betamethasone / iodixanol / lidocaine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Group I antiarrhythmics
Therapeutic duplication
The recommended maximum number of medicines in the 'group I antiarrhythmics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'group I antiarrhythmics' category:
- adenosine / lidocaine / magnesium sulfate
- betamethasone / iodixanol / lidocaine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Local injectable anesthetics
Therapeutic duplication
The recommended maximum number of medicines in the 'local injectable anesthetics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'local injectable anesthetics' category:
- adenosine / lidocaine / magnesium sulfate
- betamethasone / iodixanol / lidocaine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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