Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- black cohosh
- cisplatin
Interactions between your drugs
CISplatin black cohosh
Applies to: cisplatin, black cohosh
GENERALLY AVOID: Preliminary data from an animal model suggest that black cohosh (Cimicifuga racemosa rhizome) may reduce the cytotoxic effect of cisplatin on breast cancer cells. Mouse mammary tumor cells exposed to a high concentration of black cohosh (Cimicifuga racemosa rhizome) (100 times the recommended dose) were found to be slightly more resistant to cisplatin than were cells treated with cisplatin alone or cisplatin plus vehicle. The clinical significance in humans is unknown.
MANAGEMENT: Until more data are available, investigators of the study suggest that patients with breast cancer be discouraged from taking black cohosh (Cimicifuga racemosa rhizome).
References (1)
- Rockwell S, Liu Y, Higgins SA (2005) "Alteration of the effects of cancer therapy agents on breast cancer cells by the herbal medicine black cohosh." Breast Cancer Res Treat, 90, p. 233-9
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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