Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- encorafenib
- ubrogepant
Interactions between your drugs
encorafenib ubrogepant
Applies to: encorafenib, ubrogepant
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Coadministration with potent inducers of CYP450 3A4 may significantly decrease the plasma concentrations of ubrogepant, which is primarily metabolized by the isoenzyme. When ubrogepant was administered with the potent CYP450 3A4 inducer rifampin during in vivo studies, ubrogepant systemic exposure (AUC) decreased by 80%. Reduced efficacy of ubrogepant may occur.
MANAGEMENT: Concomitant use of ubrogepant with potent CYP450 3A4 inducers should be avoided.
Drug and food interactions
encorafenib food
Applies to: encorafenib
You should preferably avoid consumption of grapefruit and grapefruit juice while taking encorafenib. Grapefruit and grapefruit juice can significantly increase the blood levels of encorafenib. This may increase the risk of serious side effects such as bleeding complications, eye and vision problems, liver problems, irregular heart rhythm, and development of new skin cancers. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
ubrogepant food
Applies to: ubrogepant
Grapefruit and grapefruit juice can increase the blood levels of ubrogepant. This may increase side effects such as nausea and sleepiness. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe an alternative that does not interact, or you may need a different dose to safely use your medication with grapefruit and grapefruit juice. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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