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Drug Interaction Report

3 potential interactions and/or warnings found for the following 2 drugs:

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Interactions between your drugs

Moderate

vilazodone encorafenib

Applies to: vilazodone, encorafenib

Consumer information for this interaction is not currently available.

ADJUST DOSE: Coadministration with potent inducers of CYP450 3A4 may decrease the plasma concentrations and pharmacologic effects of vilazodone, which is primarily metabolized by the isoenzyme. According to the product labeling, concomitant use of vilazodone with potent CYP450 3A4 inducers such as carbamazepine can decrease vilazodone systemic exposure by approximately 45%.

MANAGEMENT: The possibility of diminished therapeutic response to vilazodone should be considered during coadministration with potent CYP450 3A4 inducers such as carbamazepine, enzalutamide, phenobarbital, phenytoin, and rifampin. When concomitant use is prescribed for greater than 14 days, an increase in the vilazodone dosage up to 2-fold may be considered depending on clinical response, up to a maximum of 80 mg daily. Following discontinuation of the CYP450 3A4 inducer, the dosage of vilazodone should be returned to the original level in 14 days.

Drug and food interactions

Major

encorafenib food

Applies to: encorafenib

You should preferably avoid consumption of grapefruit and grapefruit juice while taking encorafenib. Grapefruit and grapefruit juice can significantly increase the blood levels of encorafenib. This may increase the risk of serious side effects such as bleeding complications, eye and vision problems, liver problems, irregular heart rhythm, and development of new skin cancers. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

vilazodone food

Applies to: vilazodone

Do not drink alcohol while you are taking vilazodone. It can increase some of the side effects including dizziness, drowsiness, and difficulty concentrating. Food significantly increases the absorption of vilazodone. You should take vilazodone with a meal, preferably at the same time each day. Taking it on an empty stomach may lead to inadequate blood levels and reduced effectiveness of the medication. Talk to your doctor or pharmacist if you have any questions or concerns.

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Therapeutic duplication warnings

No duplication warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.


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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.