Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- lesinurad
- lazertinib
Interactions between your drugs
lesinurad lazertinib
Applies to: lesinurad, lazertinib
MONITOR: Coadministration with weak inducers of CYP450 3A4 may reduce the plasma levels and effects of lazertinib, which is primarily metabolized by the isoenzyme. In a phase 1 study of healthy adult participants, concomitant use of the strong CYP450 3A4 inducer rifampin reduced the peak plasma concentration (Cmax) and systemic exposure (AUC) of lazertinib by 72% and 83%, respectively. Likewise, a pharmacokinetic model predicted that concomitant use with the moderate CYP450 3A4 inducer efavirenz would decrease lazertinib's steady state Cmax and AUC by at least 32% and 44%, respectively. Clinical data with less potent CYP450 3A4 inducers are not available.
MANAGEMENT: The potential for diminished pharmacologic effects of lazertinib should be considered if coadministration with a weak CYP450 3A4 inducer is clinically necessary. An alternative concomitant medication with no potential to induce CYP450 3A4 may be required.
References (2)
- (2024) "Product Information. Lazcluze (lazertinib)." Janssen Biotech, Inc.
- Janssen Research & Development, LLC (2024) A study to assess the effects of itraconazole and rifampin on lazertinib in healthy adult participants. https://clinicaltrials.gov/study/NCT04410094?tab=table
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Zyloprim
Zyloprim is used for calcium oxalate calculi with hyperuricosuria, gout, hyperuricemia secondary to ...
Uloric
Uloric (febuxostat) reduces the production of uric acid in your body and is used to treat gout ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Krystexxa
Krystexxa (pegloticase) is an enzyme that metabolizes uric acid and is used to treat chronic gout ...
Benemid
Benemid is used for adjunct to antibiotic therapy, gout, gouty arthritis
Aloprim
Aloprim is used for calcium oxalate calculi with hyperuricosuria, gout, hyperuricemia secondary to ...
Duzallo
Duzallo (allopurinol and lesinurad) is used to reduce blood levels of uric acid in adults with ...
Medrol
Medrol is used for allergic rhinitis, asthma, asthma, acute, asthma, maintenance, congenital ...
Advil
Advil (ibuprofen) reduces fever, pain and inflammation caused by headaches, toothaches, arthritis ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.