Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- donepezil / memantine
- trospium / xanomeline
Interactions between your drugs
donepezil trospium
Applies to: donepezil / memantine, trospium / xanomeline
Using donepezil together with trospium may decrease the benefits of donepezil in the treatment of dementia. Donepezil may also counteract the benefit of trospium. Trospium should generally be avoided in patients with Alzheimer's disease or other cognitive problems. Trospium may also adversely affect elderly patients by producing symptoms ranging from mild thinking impairment to delirium. It is important that you tell your healthcare provider about all other medications that you are using including vitamins and herbs. Do not stop using your medications without first talking to your doctor.
Drug and food interactions
trospium food
Applies to: trospium / xanomeline
Trospium should be taken on an empty stomach 1 hour before or 2 hours after a meal unless otherwise directed by your doctor. You may experience reduced absorption of trospium in the presence of food. This will make it easier for your body to absorb the medication.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Cholinergics
Therapeutic duplication
The recommended maximum number of medicines in the 'cholinergics' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'cholinergics' category:
- donepezil / memantine
- trospium / xanomeline
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Aricept
Aricept is used to treat mild to severe dementia caused by Alzheimer's disease. Learn about side ...
Namenda
Namenda is used to treat dementia associated with Alzheimer's disease. Learn about side effects ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Leqembi
Leqembi (lecanemab) is used to treat Alzheimer’s disease to help slow the progression of dementia s ...
Exelon
Exelon (rivastigmine) is used to treat dementia caused by Alzheimer's or Parkinson's disease ...
Kisunla
Kisunla (donanemab) is used to treat Alzheimer’s disease to help slow down the decline in memory, t ...
Namzaric
Namzaric (memantine/donepezil) is used to treat Alzheimer's Disease. Includes Namzaric side ...
Razadyne
Razadyne information from Drugs.com, includes Razadyne side effects, interactions and indications.
Aduhelm
Aduhelm is a prescription medicine used to treat people with Alzheimer’s disease. Includes Aduhelm s ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.