Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- mirabegron
- vibegron
Interactions between your drugs
mirabegron vibegron
Applies to: mirabegron, vibegron
MONITOR: Concomitant use of vibegron with antimuscarinic agents used in the treatment of overactive bladder (OAB) may increase the risk of urinary retention. Urinary retention has been reported in clinical trials and in the postmarketing period with use of vibegron.
MANAGEMENT: Caution is advised if vibegron is prescribed in combination with antimuscarinic medications used for the treatment of OAB. Vibegron should be discontinued in patients who develop urinary retention.
References
- (2021) "Product Information. Gemtesa (vibegron)." Urovant Sciences, Inc
Drug and food interactions
mirabegron food
Applies to: mirabegron
Food reduces the oral absorption and bioavailability of mirabegron. According to the product labeling, administration of a 50 mg tablet with a high-fat meal decreased mirabegron peak plasma concentration (Cmax) and systemic exposure (AUC) by 45% and 17%, respectively, whereas administration with a low-fat meal decreased mirabegron Cmax and AUC by 75% and 51%, respectively. In phase 3 clinical studies demonstrating both safety and efficacy, mirabegron was administered without regards to food content and intake. Therefore, mirabegron can be taken with or without food at the recommended dosage.
References
- (2012) "Product Information. Myrbetriq (mirabegron)." Astellas Pharma US, Inc
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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