Drug Interaction Report

Consumer information for this interaction is not currently available.

MONITOR: Coadministration of momelotinib may decrease the plasma concentrations and effects of drugs that are substrates of CYP450 1A2. The proposed mechanism, based on in vitro data, is increased drug clearance due to momelotinib-mediated induction of the CYP450 1A2 isoenzyme. However, clinical data are not available.

MANAGEMENT: Caution is recommended with the concomitant use of momelotinib and CYP450 1A2 substrates, particularly those with a narrow therapeutic index. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever momelotinib is added to or withdrawn from therapy with these drugs. Individual product labeling for the coadministered drug may also be consulted for specific guidance.

Information for this minor interaction is available on the professional version.

Ask your doctor before using aspirin together with ethanol (alcohol). Do not drink alcohol while taking aspirin. Alcohol can increase your risk of stomach bleeding caused by aspirin. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Information for this minor interaction is available on the professional version.

Information for this minor interaction is available on the professional version.