Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- Mintezol (thiabendazole)
- ritlecitinib
Interactions between your drugs
thiabendazole ritlecitinib
Applies to: Mintezol (thiabendazole), ritlecitinib
MONITOR: Coadministration with ritlecitinib may increase the plasma concentrations and effects of drugs that are primarily metabolized by the CYP450 1A2 isoenzyme. The mechanism is reduced clearance due to inhibition of CYP450 1A2 by ritlecitinib. When ritlecitinib (200 mg once daily for 9 days) was administered in combination with the sensitive CYP450 1A2 substrate caffeine, the mean peak plasma concentration (Cmax) and systemic exposure (AUC) of caffeine increased by 1.10- and 2.65-fold, compared to administration of caffeine alone. The interaction may be significant for sensitive CYP450 1A2 substrates or those that demonstrate a narrow therapeutic index.
MANAGEMENT: Caution is advised with the concomitant use of ritlecitinib with CYP450 1A2 substrates, particularly sensitive substrates or those that demonstrate a narrow therapeutic index. If concomitant use is required, clinical and laboratory monitoring may be appropriate whenever ritlecitinib is added to or withdrawn from therapy. The prescribing information for concomitant medications should be consulted to assess the benefits versus risks of coadministration and for any dosage adjustments that may be required.
References (1)
- (2023) "Product Information. Litfulo (ritlecitinib)." Pfizer U.S. Pharmaceuticals Group
Drug and food interactions
thiabendazole food
Applies to: Mintezol (thiabendazole)
MONITOR: Coadministration with thiabendazole may increase the plasma concentrations of caffeine. The mechanism is thiabendazole inhibition of the CYP450 1A2 metabolism of caffeine. In ten healthy, nonsmoking volunteers, administration of a single 136.5 mg dose of caffeine in combination with a single 500 mg dose of thiabendazole resulted in a nearly 60% increase in the area under the plasma concentration-time curve (AUC) of caffeine compared to administration without thiabendazole. In addition, the half-life of caffeine was increased from 11.9 to 28.6 hours, and oral clearance was reduced by 67% during coadministration with thiabendazole. The formation of paraxanthine from caffeine, which is primarily mediated by CYP450 1A2, was almost completely abolished until after the thiabendazole was cleared from the system.
MANAGEMENT: Patients should be advised that pharmacologic effects of caffeine may be increased during coadministration with thiabendazole.
References (2)
- Bapiro TE, Sayi J, Hasler JA, et al. (2005) "Artemisinin and thiabendazole are potent inhibitors of cytochrome P450 1A2 (CYP1A2) activity in humans." Eur J Clin Pharmacol, 61, p. 755-61
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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