Drug Interaction Report

Before taking salsalate, tell your doctor if you also use divalproex sodium. You may need dose adjustments or special tests in order to safely take both medications together. Small single doses of salsalate are unlikely to cause significant effects. However, if you take salsalate over a prolonged period of time you may need your divalproex sodium levels checked. You should notify your doctor if you have symptoms of fever, weakness, drowsiness, nausea, vomiting, or stomach pain. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Alcohol can increase the nervous system side effects of divalproex sodium such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with divalproex sodium. Do not use more than the recommended dose of divalproex sodium, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Ask your doctor before using salsalate together with ethanol (alcohol). Do not drink alcohol while taking salsalate. Alcohol can increase your risk of stomach bleeding caused by salsalate. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.