Drug Interaction Report

Raloxifene is more than 95% protein bound. Caution should be exercised if raloxifene is coadministered with other highly protein-bound drugs. The mechanism is displacement of the drug from its protein-binding site by raloxifene. Displacement may lead to increased free plasma concentrations and potentiate toxicity of drugs affected by raloxifene. Formal in-vitro studies indicate that raloxifene did not affect the binding of warfarin, phenytoin, or tamoxifen. The clinician may want to use caution when raloxifene is used with other highly-protein bound drugs, such as diazepam, diazoxide, or lidocaine.