Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- primaquine
- quinacrine
Interactions between your drugs
quinacrine primaquine
Applies to: quinacrine, primaquine
CONTRAINDICATED: Coadministration of primaquine and quinacrine may result in additive toxicity such as bone marrow depression and hemolytic anemia. Quinacrine has been reported to potentiate the toxicity of other antimalarial agents that are structurally related to primaquine.
MANAGEMENT: The concurrent use of primaquine and quinacrine is considered contraindicated. Primaquine should also not be administered to patients who have recently received quinacrine.
References (1)
- (2001) "Product Information. Primaquine (primaquine)." Sanofi Winthrop Pharmaceuticals
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Antimalarials
Therapeutic duplication
The recommended maximum number of medicines in the 'antimalarials' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'antimalarials' category:
- primaquine
- quinacrine
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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