Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- phenobarbital
- tovorafenib
Interactions between your drugs
PHENobarbital tovorafenib
Applies to: phenobarbital, tovorafenib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inducers of CYP450 2C8 may decrease the plasma concentrations and pharmacologic effects of tovorafenib, which has been found in vitro to be primarily metabolized by CYP450 2C8 and aldehyde oxidase, and to a lesser extent, by the isoenzymes CYP450 3A, 2C9, and 2C19. However, data from formal clinical drug interaction studies are not available.
MANAGEMENT: Caution is advised if tovorafenib is to be used concomitantly with CYP450 2C8 inducers. Patients should be monitored for diminished therapeutic effect. Clinical and laboratory monitoring may also be considered whenever a CYP450 2C8 inducer is added to or withdrawn from therapy. Alternative therapy may need to be considered if a drug interaction is suspected.
Drug and food interactions
PHENobarbital food
Applies to: phenobarbital
Ask your doctor before using PHENobarbital together with ethanol, this can add to dizziness, drowsiness and other side effects of PHENobarbital. Be careful if you drive or do activities that require you to be awake and alert. Talk with your doctor before using any medications together, or drinking alcohol with PHENobarbital. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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