Drug Interaction Report
2 potential interactions and/or warnings found for the following 2 drugs:
- omeprazole / sodium bicarbonate
- vorasidenib
Interactions between your drugs
omeprazole vorasidenib
Applies to: omeprazole / sodium bicarbonate, vorasidenib
GENERALLY AVOID: Concomitant use with inducers of CYP450 1A2 may decrease the plasma concentrations and anti-tumor effects of vorasidenib, which is primarily metabolized by the isoenzyme. The moderate CYP450 1A2 inducers, phenytoin or rifampin, are predicted to decrease the steady state peak plasma concentration (Cmax) and systemic exposure (AUC) of vorasidenib by 30% and 40%, respectively.
MANAGEMENT: Concomitant use of vorasidenib with CYP450 1A2 inducers should be avoided.
References (1)
- (2024) "Product Information. Voranigo (vorasidenib)." Servier Pharmaceuticals LLC
Drug and food interactions
vorasidenib food
Applies to: vorasidenib
GENERALLY AVOID: Due to induction of CYP450 1A2, the isoenzyme primarily responsible for the metabolic clearance of vorasidenib, smoking tobacco during treatment with vorasidenib may decrease its plasma concentrations and anti-tumor effect. Clinical and pharmacokinetic data are currently lacking.
MANAGEMENT: Patient should be advised to avoid smoking tobacco during treatment with vorasidenib because it may reduce efficacy of the therapy.
References (1)
- (2024) "Product Information. Voranigo (vorasidenib)." Servier Pharmaceuticals LLC
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Protonix
Protonix (pantoprazole) is used to treat erosive esophagitis and other conditions involving excess ...
Nexium
Nexium is used to treat GERD and other conditions involving excessive stomach acid. Learn about ...
Ozempic
Learn about Ozempic (semaglutide) for type 2 diabetes treatment, weight management, cardiovascular ...
Pepcid
Pepcid is used to treat ulcers in the stomach and for conditions where the stomach produces too ...
Prilosec
Prilosec (omeprazole) is used to treat symptoms of GERD and other conditions caused by excess ...
Carafate
Carafate is an anti-ulcer medication used to treat active duodenal ulcers. Learn about side ...
Prevacid
Prevacid is used to treat and prevent stomach and intestinal ulcers. Learn about side effects ...
Zantac
Zantac is used to treat and prevent ulcers in the stomach and intestines. Includes Zantac side ...
Dexilant
Dexilant is used for barrett's esophagus, erosive esophagitis, GERD
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.