Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- amikacin
- Mezlin (mezlocillin)
Interactions between your drugs
amikacin mezlocillin
Applies to: amikacin, Mezlin (mezlocillin)
ADJUST DOSING INTERVAL: Mezlocillin may inactivate aminoglycosides in vivo and in vitro. The mechanism is complexation with the aminoglycoside. Typically, this effect is significant only in patients with renal failure or if the agents are mixed in the same IV container or line. Lower serum aminoglycoside levels may be seen, and dosage adjustments may be necessary.
MANAGEMENT: Mezlocillin and aminoglycosides should be administered separately during combined therapy.
References (11)
- Riff LJ, Jackson GG (1972) "Laboratory and clinical conditions for gentamicin inactivation by carbenicillin." Arch Intern Med, 130, p. 887-91
- Davies M, Morgan JR, Anand C (1975) "Interactions of carbenicillin and ticarcillin with gentamicin." Antimicrob Agents Chemother, 7, p. 431-4
- Thompson MI, Russo ME, Saxon BJ, Atkin-Thor E, Matsen JM (1982) "Gentamicin inactivation by piperacillin or carbenicillin in patients with end-stage renal disease." Antimicrob Agents Chemother, 21, p. 268-72
- Halstenson CE, Hirata CA, Heim-Duthoy KL, Abraham PA, Matzke GR (1990) "Effect of concomitant administration of piperacillin on the dispositions of netilmicin and tobramycin in patients with end-stage renal disease." Antimicrob Agents Chemother, 34, p. 128-33
- Kradjan WA, Burger R (1980) "In vivo inactivation of gentamycin by carbenicillin and ticarcillin." Arch Intern Med, 140, p. 1668-70
- Russo ME, Atkin-Thor E (1981) "Gentamicin and ticarcillin in subjects with end-stage renal disease." Clin Nephrol, 15, p. 175-80
- Viollier AF, Standiford HC, Drusano GL, Tatem BA, Moody MR, Schimpff SC (1985) "Comparative pharmacokinetics and serum bactericidal activity of mezlocillin, ticarcillin and piperacillin, with and without gentamicin." J Antimicrob Chemother, 15, p. 597-606
- Weibert R, Keane W, Shapiro F (1976) "Carbenicillin inactivation of aminoglycosides in patients with severe renal failure." Trans Am Soc Artif Intern Organs, 22, p. 439-43
- Pickering LK, Rutherford I (1981) "Effect of concentration and time upon inactivation of tobramycin, gentamicin, netilmicin and amikacin by azlocillin, carbenicillin, mecillinam, mezlocillin and piperacillin." J Pharmacol Exp Ther, 217, p. 345-9
- Henderson JL, Polk RE, Kline BJ (1981) "In vitro inactivation of gentamicin, tobramycin, and netilmicin by carbenicillin, azlocillin, or mezlocillin." Am J Hosp Pharm, 38, p. 1167-70
- (2018) "Product Information. Arikayce (amikacin liposome)." Insmed Incorporated
Drug and food interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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