Drug Interaction Report
3 potential interactions and/or warnings found for the following 2 drugs:
- isotretinoin
- niacinamide / tazarotene topical
Interactions between your drugs
ISOtretinoin tazarotene topical
Applies to: isotretinoin, niacinamide / tazarotene topical
GENERALLY AVOID: Concomitant use of isotretinoin with topical exfoliative or keratolytic anti-acne agents may increase local skin irritation.
MANAGEMENT: Concurrent use should generally be avoided.
References (2)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Pharmaceutical Society of Australia (2006) APPGuide online. Australian prescription products guide online. http://www.appco.com.au/appguide/default.asp
Drug and food interactions
ISOtretinoin food
Applies to: isotretinoin
GENERALLY AVOID: The combined use of ethanol and isotretinoin may result in a disulfiram-like reaction. The mechanism has not been established.
MANAGEMENT: Alcohol consumption should be avoided during isotretinoin therapy.
References (1)
- (2001) "Product Information. Accutane (isotretinoin)." Roche Laboratories
Therapeutic duplication warnings
Therapeutic duplication is the use of more than one medicine from the same drug category or therapeutic class to treat the same condition. This can be intentional in cases where drugs with similar actions are used together for demonstrated therapeutic benefit. It can also be unintentional in cases where a patient has been treated by more than one doctor, or had prescriptions filled at more than one pharmacy, and can have potentially adverse consequences.
Retinoic acid derivatives
Therapeutic duplication
The recommended maximum number of medicines in the 'retinoic acid derivatives' category to be taken concurrently is usually one. Your list includes two medicines belonging to the 'retinoic acid derivatives' category:
- isotretinoin
- niacinamide / tazarotene topical
Note: In certain circumstances, the benefits of taking this combination of drugs may outweigh any risks. Always consult your healthcare provider before making changes to your medications or dosage.
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Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
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Further information
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