Drug Interaction Report
1 potential interaction and/or warning found for the following 2 drugs:
- fosphenytoin
- Lipidil EZ (fenofibrate)
Interactions between your drugs
fosphenytoin fenofibrate
Applies to: fosphenytoin, Lipidil EZ (fenofibrate)
MONITOR: Coadministration with fenofibrate may increase the plasma concentrations and risk of adverse effects of drugs that are substrates of CYP450 2C19, 2A6, and 2C9 isoenzymes. The proposed mechanism, based on in vitro data, is decreased clearance due to fenofibrate-mediated inhibition of CYP450 2C19, 2A6, and 2C9.
MANAGEMENT: Until more information is available, caution is advised if fenofibrate is used concomitantly with drugs that are substrates of CYP450 2C19, 2A6, or 2C9 isoenzymes, particularly those with a narrow therapeutic range. Dosage adjustments as well as clinical and laboratory monitoring should be considered whenever fenofibrate is added to or withdrawn from therapy with these drugs. Patients should be monitored for the development of adverse effects.
References (3)
- Cerner Multum, Inc. "UK Summary of Product Characteristics."
- Cerner Multum, Inc. "Australian Product Information."
- (2016) "Product Information. Antara (fenofibrate)." Lupin Pharmaceuticals Inc
Drug and food/lifestyle interactions
No alcohol/food interactions were found with the drugs in your list. However, this does not necessarily mean no food interactions exist. Always consult your healthcare provider.
Therapeutic duplication warnings
No duplication warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
Report options
- Switch to consumer interaction data
- Email this report to a friend, doctor, or patient
- Ask questions, find answers
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
See also:
Ativan
Ativan is a benzodiazepine used to treat anxiety disorders or anxiety associated with depression ...
Valium
Valium is used to treat anxiety disorders, alcohol withdrawal symptoms, or muscle spasms. Learn ...
Botox
Botox is used cosmetically to reduce facial lines and wrinkles and for medical purposes for ...
Dilantin
Dilantin (phenytoin) is an anti-epileptic drug used to control seizures. Includes Dilantin side ...
Versed
Versed is used for ICU Agitation, light anesthesia, light sedation
Nayzilam
Nayzilam (midazolam) is used to treat seizure clusters. Information includes Nayzilam side effects ...
Valtoco
Valtoco nasal spray is used for the acute treatment of intermittent seizure clusters (also known as ...
Midazolam
Midazolam is used for ICU Agitation, light anesthesia, light sedation, seizures, status epilepticus
Phenytoin
Phenytoin is an anti-epileptic drug, also called an anticonvulsant. Learn about side effects ...
Learn more
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Check Interactions
To view an interaction report containing 4 (or more) medications, please sign in or create an account.
Save Interactions List
Sign in to your account to save this drug interaction list.