Pregelatinized Corn Starch
Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Oct 26, 2020.
What is it?
Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. Disintegrants enable tablets and capsules to break down into smaller fragments (dissolve) so that the drug can be released for absorption.[1] Starches also absorb water rapidly, allowing tablets to disintegrate appropriately.
Starches are also used in the food manufacturing industry for processing, and as food thickeners or stabilizers. There are many other diverse uses for starches in the manufacturing industry. Pregelatinized starch derives primarily from corn, has been cooked and then dried. Instant puddings, pie fillings, soup mixes, salad dressings, and candy often contain pregelatinized starch.[2]
Pregelatinized starches (dried, cooked starches) are highly digestible. Consumption of excessive quantities of raw starch has resulted in obesity and iron-deficiency anemia in human subjects. However, there is no evidence to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.[3]
Top Medications with this excipient
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 7.5 mg
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 7.5 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg
- Acetaminophen Extended Release 650 mg
- Amitriptyline Hydrochloride 25 mg
- Extra Pain Relief acetaminophen 250 mg / aspirin 250 mg / caffeine 65 mg
- Furosemide 20 mg
- Furosemide 40 mg
- Ibuprofen 800 mg
- Loratadine 10 mg
- Loratadine and Pseudoephedrine Sulfate Extended Release 10 mg / 240 mg
- Topiramate 25 mg
- Topiramate 50 mg
- Trazodone Hydrochloride 50 mg
- Trazodone Hydrochloride 100 mg
- Trazodone Hydrochloride 50 mg
References
[1] [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] David A Bender. Starch, Pregelatinized. A Dictionary of Food and Nutrition. 2005. Retrieved March 19, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O39-starchpregelatinized.html
[3] FDA’s SCOGS database; Wheat Starch; SCOGS-Report Number: 115; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=365 Accessed March 19, 2012.
Further information
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