Pregelatinized Corn Starch
Excipient (pharmacologically inactive substance)
What is it?
Starches are typically derived from corn or potato. Starches are used in the pharmaceutical industry for a wide variety of reasons, such as an excipient, a tablet and capsule diluent, a tablet and capsule disintegrant, a glidant, or as binder. Disintegrants enable tablets and capsules to break down into smaller fragments (dissolve) so that the drug can be released for absorption.[1] Starches also absorb water rapidly, allowing tablets to disintegrate appropriately.
Starches are also used in the food manufacturing industry for processing, and as food thickeners or stabilizers. There are many other diverse uses for starches in the manufacturing industry. Pregelatinized starch derives primarily from corn, has been cooked and then dried. Instant puddings, pie fillings, soup mixes, salad dressings, and candy often contain pregelatinized starch.[2]
Pregelatinized starches (dried, cooked starches) are highly digestible. Consumption of excessive quantities of raw starch has resulted in obesity and iron-deficiency anemia in human subjects. However, there is no evidence to suspect a hazard to the public when they are used at levels that are now current or that might reasonably be expected in the future.[3]
[1] [1]Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
[2] David A Bender. Starch, Pregelatinized. A Dictionary of Food and Nutrition. 2005. Retrieved March 19, 2012 from Encyclopedia.com: http://www.encyclopedia.com/doc/1O39-starchpregelatinized.html
[3] FDA’s SCOGS database; Wheat Starch; SCOGS-Report Number: 115; http://www.accessdata.fda.gov/scripts/fcn/fcnDetailNavigation.cfm?rpt=scogsListing&id=365 Accessed March 19, 2012.
Top Medications with this excipient
- Acetaminophen and Hydrocodone Bitartrate 325 mg / 5 mg (Watson Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg (Qualitest Pharmaceuticals Inc.)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 10 mg (Watson Pharmaceuticals)
- Acetaminophen and Oxycodone Hydrochloride 325 mg / 5 mg (Watson Pharmaceuticals)
- Acetaminophen and Tramadol Hydrochloride 325 mg / 37.5 mg (Zydus Pharmaceuticals USA Inc.)
- Acetaminophen Extended Release 650 mg (Chain Drug Marketing Assoc)
- Hydrochlorothiazide and Lisinopril 12.5 mg / 20 mg (Lupin Pharmaceuticals, Inc)
- Hydrochlorothiazide and Lisinopril 12.5 mg / 10 mg (Lupin Pharmaceuticals, Inc)
- Hydrochlorothiazide and Lisinopril 25 mg / 20 mg (Lupin Pharmaceuticals, Inc)
- Hydrocodone Bitartrate and Ibuprofen 7.5 mg / 200 mg (Watson Laboratories, Inc.)
- Ibuprofen 800 mg (Marksans Pharma Inc.)
- Ibuprofen 600 mg (Marksans Pharma Inc.)
- Lisinopril 10 mg (Lupin Pharmaceuticals, Inc)
- Lisinopril 20 mg (Lupin Pharmaceuticals, Inc)
- Lisinopril 5 mg (Lupin Pharmaceuticals, Inc)
- Lisinopril 40 mg (Lupin Pharmaceuticals, Inc)
- Methocarbamol 750 mg (Qualitest Pharmaceuticals Inc.)
- Methocarbamol 500 mg (Qualitest Pharmaceuticals Inc.)
- Norco 325 mg / 5 mg (Watson Pharmaceuticals)
- Prednisone 10 mg (Qualitest Pharmaceuticals Inc.)
