Excipient (pharmacologically inactive substance)
Medically reviewed by Drugs.com. Last updated on Dec 10, 2020.
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
Top Medications with this excipient
- Cetirizine Hydrochloride 10 mg
- Clarithromycin 500 mg
- Demeclocycline Hydrochloride 300 mg
- Dilotab II acetaminophen 325 mg / phenylephrine hydrochloride 5 mg
- Fosinopril Sodium 40 mg
- Glyburide 5 mg
- Glyburide and Metformin Hydrochloride 2.5 mg / 500 mg
- Lamotrigine 100 mg
- Lamotrigine 200 mg
- Levothroid 200 mcg (0.2 mg)
- Levothroid 88 mcg (0.088 mg)
- Levothroid 137 mcg (0.137 mg)
- Levothroid 112 mcg (0.112 mg)
- Levothroid 100 mcg (0.1 mg)
- Liptruzet atorvastatin 80 mg / ezetimibe 10 mg
- Memantine Hydrochloride 10 mg
- Pramipexole Dihydrochloride 0.125 mg
- Roweepra 250 mg
- Ursodiol 250 mg
- Voriconazole 50 mg
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
 Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
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