Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
 Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Top Medications with this excipient
- Atenolol and Chlorthalidone 50 mg / 25 mg
- Clonidine Hydrochloride 0.1 mg
- Clonidine Hydrochloride 0.2 mg
- Clonidine Hydrochloride 0.3 mg
- ConZip 200 mg
- Dipyridamole 50 mg
- Divalproex Sodium Delayed Release 125 mg
- Guanfacine Hydrochloride 1 mg
- Hydrochlorothiazide and Irbesartan 12.5 mg / 150 mg
- Hydrochlorothiazide and Moexipril Hydrochloride 25 mg / 15 mg
- Irbesartan 150 mg
- Lamotrigine 25 mg
- Lamotrigine (Chewable, Dispersible) 25 mg
- Levothroid 75 mcg (0.075 mg)
- Liptruzet atorvastatin 40 mg / ezetimibe 10 mg
- Meloxicam 15 mg
- Meloxicam 7.5 mg
- Rapamune 0.5 mg
- Urso Forte 500 mg
- Valcyte 450 mg