Excipient (pharmacologically inactive substance)
What is it?
Povidone (polyvinylpyrrolidone, PVP) is used in the pharmaceutical industry as a synthetic polymer vehicle for dispersing and suspending drugs. It has multiple uses, including as a binder for tablets and capsules, a film former for ophthalmic solutions, to aid in flavoring liquids and chewable tablets, and as an adhesive for transdermal systems.
Povidone has the molecular formula of (C6H9NO)n and appears as a white to slightly off-white powder. Povidone formulations are widely used in the pharmaceutical industry due to their ability to dissolve in both water and oil solvents. The k number refers to the mean molecular weight of the povidone. Povidones with higher K-values (i.e., k90) are not usually given by injection due to their high molecular weights. The higher molecular weights prevent excretion by the kidneys and lead to accumulation in the body. The best-known example of povidone formulations is povidone-iodine, an important disinfectant.
 Dave RH. Overview of pharmaceutical excipients used in tablets and capsules. Drug Topics (online). Advanstar. 10/24/2008 http://drugtopics.modernmedicine.com/drugtopics/Top+News/Overview-of-pharmaceutical-excipients-used-in-tabl/ArticleStandard/Article/detail/561047. Accessed 08/19/2011
 Folttman H, Quadir A. Excipent Update. Polyvinylpyrrolidone (PVP) - one of the mosy widely used excipients in pharmaceuricals: an overview. Drug Delivery Technology. Vol 8;6:22-7. Accessed April 9, 2012. http://www.pharma-ingredients.basf.com/Documents/ENP/Review%20Articles/DDT-June-2008.pdf
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Top Medications with this excipient
- Cetirizine Hydrochloride 5 mg
- Clonidine Hydrochloride 0.1 mg
- Clonidine Hydrochloride 0.2 mg
- Demeclocycline Hydrochloride 150 mg
- Divalproex Sodium Delayed Release 125 mg
- Guanfacine Hydrochloride 2 mg
- Lamotrigine 200 mg
- Levothroid 300 mcg (0.3 mg)
- Levothroid 0.125 mg
- Levothroid 200 mcg (0.2 mg)
- Liptruzet atorvastatin 20 mg / ezetimibe 10 mg
- Meloxicam 15 mg
- Meloxicam 7.5 mg
- Minocycline Hydrochloride 50 mg
- Pramipexole Dihydrochloride 1.5 mg
- Pravastatin Sodium 10 mg
- Pravastatin Sodium 80 mg
- Probenecid 500 mg
- Propranolol Hydrochloride Extended-Release 80 mg
- Terbutaline Sulfate 2.5 mg