Renagel (sevelamer) and Alcohol / Food Interactions
There are 2 alcohol/food/lifestyle interactions with Renagel (sevelamer) which include:
multivitamins with minerals ↔ sevelamer
Moderate Drug Interaction
Consumer information for this interaction is not currently available.
ADJUST DOSING INTERVAL: Bile acid sequestrants and the phosphate binder, sevelamer, can decrease the absorption of fat-soluble vitamins A, D, E, and K. In non-clinical safety studies, rats administered colesevelam at doses greater than 30-fold the projected human clinical dose developed hemorrhage in association with vitamin K deficiency. In a crossover study involving healthy subjects, coadministration of sevelamer with calcitriol resulted in a significant reduction in bioavailability for calcitriol (calcitriol with sevelamer vs calcitriol alone: AUC 137 pg*h/mL vs 318 pg*h/mL and Cmax 40.1 pg/mL vs 49.7 pg/mL, respectively).
MANAGEMENT: Oral vitamin supplements should be administered at least 4 hours before colesevelam and either 1 hour before or 4 to 6 hours after other bile acid sequestrants and sevelamer.
- Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0
- Cerner Multum, Inc. "Australian Product Information." O 0
- Peirce D, Hossack S, Poole L, et.al "The effect of sevelamer carbonate and lanthanum carbonate on the pharmacokinetics of oral calcitriol." Nephrol Dial Transplant 26 (2011): 1615-21
- "Product Information. Rocaltrol (calcitriol)." Roche Laboratories, Nutley, NJ.
- "Product Information. Welchol (colesevelam)" Daiichi Sankyo, Inc., Parsippany, NJ.
sevelamer ↔ food
Moderate Food Interaction
Sevelamer may interact with other medications if taken directly with them. As a precaution, other medications that can be affected by changes in blood levels should be administered 1 hour before or 3 hours after sevelamer. This will make it easier for your body to absorb the medication.
Renagel (sevelamer) drug Interactions
There are 49 drug interactions with Renagel (sevelamer)
Renagel (sevelamer) disease Interactions
There are 3 disease interactions with Renagel (sevelamer) which include:
More about Renagel (sevelamer)
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- Drug class: phosphate binders
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.