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Fycompa (perampanel) and Alcohol / Food Interactions

There are 3 alcohol/food/lifestyle interactions with Fycompa (perampanel) which include:


perampanel ↔ food

Moderate Food Interaction

Alcohol can increase the nervous system side effects of perampanel such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with perampanel. Do not use more than the recommended dose of perampanel, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

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High Cholesterol (Hyperlipoproteinemia, Hypertriglyceridemia, Sitosterolemia)

Moderate Potential Hazard, Moderate plausibility

perampanel - elevated triglycerides

Increased levels of triglycerides have occurred in patients using perampanel. Care should be taken when prescribing this agent to patients with high triglycerides levels, and close monitoring of lipid profile is recommended during therapy.



Moderate Potential Hazard, Moderate plausibility

perampanel - weight gain

Weight gain has occurred with the use of perampanel. Care should be taken when prescribing this agent to patients predisposed to weight gain, and regular monitoring of weight is recommended.

Fycompa (perampanel) drug interactions

There are 648 drug interactions with Fycompa (perampanel)

Fycompa (perampanel) disease interactions

There are 5 disease interactions with Fycompa (perampanel) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.