Orudis (ketoprofen) and Alcohol / Food Interactions
There are 3 alcohol/food/lifestyle interactions with Orudis (ketoprofen) which include:
ketoprofen ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using ketoprofen together with ethanol. Do not drink alcohol while taking ketoprofen. Alcohol can increase your risk of stomach bleeding caused by ketoprofen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
High Blood Pressure (Hypertension)
Severe Potential Hazard, Moderate plausibility
NSAIDs - fluid retention
Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
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- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
- "Product Information. Orudis (ketoprofen)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- Lewis RV, Toner JM, Jackson PR, Ramsay LE "Effects of indomethacin and sulindac on blood pressure of hypertensive patients." Br Med J 292 (1986): 934-5
- "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
- Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
- Van Den Ouweland FA, Gribnau FW, Meyboom RH "Congestive heart failure due to nonsteroidal anti-inflammatory drugs in the elderly." Age Ageing 17 (1988): 8-16
- "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
- "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
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- "Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
- "Product Information. Feldene (piroxicam)." Pfizer US Pharmaceuticals, New York, NY.
- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
- Gurwitz JH, Everitt DE, Monane M, et al "The impact of ibuprofen on the efficacy of antihypertensive treatment with hydrochlorothiazide in elderly persons." J Gerontol A Biol Sci Med Sci 51 (1996): m74-9
- "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
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- "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
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- "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
- "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
NSAIDs - hypertension
NSAIDs including topicals can lead to the onset of new hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. Blood pressure should be monitored closely during NSAID therapy and throughout the course of therapy.
Orudis (ketoprofen) drug Interactions
There are 420 drug interactions with Orudis (ketoprofen)
Orudis (ketoprofen) disease Interactions
There are 12 disease interactions with Orudis (ketoprofen) which include:
- Fluid Retention
- Gi Toxicity
- Renal Toxicities
- Heart Failure
- Platelet Aggregation Inhibition
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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