Symdeko (ivacaftor / tezacaftor) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Symdeko (ivacaftor / tezacaftor):
ivacaftor ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of ivacaftor. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
ADJUST DOSING INTERVAL: According to the manufacturer, systemic exposure to ivacaftor increased approximately 2.5- to 4-fold and systemic exposure to lumacaftor increased approximately 2-fold following administration with fat-containing foods relative to administration in a fasting state. Tezacaftor exposure is not affected by administration of fat-containing foods.
MANAGEMENT: Patients treated with ivacaftor should avoid consumption of grapefruit juice and any food that contains grapefruit or Seville oranges. Ivacaftor, lumacaftor/ivacaftor, and tezacaftor/ivacaftor should all be administered with fat-containing foods such as eggs, avocados, nuts, butter, peanut butter, cheese pizza, and whole-milk dairy products. A typical cystic fibrosis diet will satisfy this requirement.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Symdeko (ivacaftor / tezacaftor) drug interactions
There are 426 drug interactions with Symdeko (ivacaftor / tezacaftor)
Symdeko (ivacaftor / tezacaftor) disease interactions
There are 3 disease interactions with Symdeko (ivacaftor / tezacaftor) which include:
More about Symdeko (ivacaftor / tezacaftor)
- Symdeko Side Effects
- During Pregnancy
- Dosage Information
- Drug Interactions
- Pricing & Coupons
- En Español
- Drug class: CFTR combinations
Related treatment guides
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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