Orkambi (ivacaftor / lumacaftor) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Orkambi (ivacaftor / lumacaftor):
ivacaftor ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Grapefruit juice may increase the plasma concentrations of ivacaftor. The proposed mechanism is inhibition of CYP450 3A4-mediated first-pass metabolism in the gut wall by certain compounds present in grapefruit.
ADJUST DOSING INTERVAL: According to the manufacturer, systemic exposure to ivacaftor increased approximately 2.5- to 4-fold and systemic exposure to lumacaftor increased approximately 2-fold following administration with fat-containing foods relative to administration in a fasting state. Tezacaftor exposure is not affected by administration of fat-containing foods.
MANAGEMENT: Patients treated with ivacaftor should avoid consumption of grapefruit juice and any food that contains grapefruit or Seville oranges. Ivacaftor, lumacaftor/ivacaftor, and tezacaftor/ivacaftor should all be administered with fat-containing foods such as eggs, avocados, nuts, butter, peanut butter, cheese pizza, and whole-milk dairy products. A typical cystic fibrosis diet will satisfy this requirement.
- "Product Information. Kalydeco (ivacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Orkambi (ivacaftor-lumacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
- "Product Information. Symdeko 4-Week (ivacaftor-tezacaftor)." Vertex Pharmaceuticals, Cambridge, MA.
Orkambi (ivacaftor / lumacaftor) drug interactions
There are 597 drug interactions with Orkambi (ivacaftor / lumacaftor)
Orkambi (ivacaftor / lumacaftor) disease interactions
There are 3 disease interactions with Orkambi (ivacaftor / lumacaftor) which include:
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- Drug class: CFTR combinations
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Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
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