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Soliqua (insulin glargine / lixisenatide) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Soliqua (insulin glargine / lixisenatide) which include:

Moderate

Alcohol (Ethanol) ↔ insulin glargine

Moderate Drug Interaction

Talk to your doctor before using ethanol together with insulin glargine. Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

Alcohol (Ethanol) ↔ lixisenatide

Moderate Drug Interaction

Talk to your doctor before using ethanol together with lixisenatide. Alcohol may affect blood glucose levels in patients with diabetes. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink. You should avoid using alcohol if your diabetes is not well controlled or if you have high triglycerides, neuropathy (nerve damage), or pancreatitis. Moderate alcohol consumption generally does not affect blood glucose levels if your diabetes is under control. However, it may be best to limit alcohol intake to one drink daily for women and two drinks daily for men (1 drink = 5 oz wine, 12 oz beer, or 1.5 oz distilled spirits) in conjunction with your normal meal plan. Avoid drinking alcohol on an empty stomach or following exercise, as it may increase the risk of hypoglycemia. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

insulin glargine ↔ Alcohol (Ethanol)

Moderate Drug Interaction

Using lixisenatide together with insulin glargine can increase the risk of hypoglycemia, or low blood sugar. You may need a dose adjustment or more frequent monitoring of your blood sugar to safely use both medications. Let your doctor know if you experience hypoglycemia during treatment. Symptoms of hypoglycemia include headache, dizziness, drowsiness, nervousness, confusion, tremor, nausea, hunger, weakness, perspiration, palpitation, and rapid heartbeat. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

lixisenatide ↔ food

Moderate Food Interaction

Consumer information for this interaction is not currently available.

ADJUST DOSING INTERVAL: Lixisenatide slows gastric emptying and may reduce the extent and rate of absorption of concomitantly administered oral medications. When paracetamol 1000 mg was administered 1 hour and 4 hours after lixisenatide injection, paracetamol systemic exposure (AUC) was decreased by 29% and 31%, respectively; and time to peak plasma concentration (Tmax) was increased by 2 hours and 1.75 hours, respectively. Cmax and AUC were not significantly changed when paracetamol was given one hour before lixisenatide injection.

MANAGEMENT: Concomitantly administered oral medications that are dependent on threshold concentrations for efficacy (e.g., antibiotics), or that are gastroresistant formulations of ingredients that are sensitive to stomach degradation, should be administered at least 1 hour before or 4 hours after lixisenatide injection. If such medications are to be administered with food, patients should be advised to take them with a meal when lixisenatide is not administered.

References

  1. Cerner Multum, Inc. "UK Summary of Product Characteristics." O 0

Soliqua (insulin glargine / lixisenatide) drug Interactions

There are 895 drug interactions with Soliqua (insulin glargine / lixisenatide)

Soliqua (insulin glargine / lixisenatide) disease Interactions

There are 7 disease interactions with Soliqua (insulin glargine / lixisenatide) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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