Motrin IB (ibuprofen) and Alcohol / Food Interactions
There are 3 alcohol/food/lifestyle interactions with Motrin IB (ibuprofen) which include:
ibuprofen ↔ Alcohol (Ethanol)
Moderate Drug Interaction
Ask your doctor before using ibuprofen together with ethanol. Do not drink alcohol while taking ibuprofen. Alcohol can increase your risk of stomach bleeding caused by ibuprofen. Call your doctor at once if you have symptoms of bleeding in your stomach or intestines. This includes black, bloody, or tarry stools, or coughing up blood or vomit that looks like coffee grounds. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
High Blood Pressure (Hypertension)
Severe Potential Hazard, Moderate plausibility
NSAIDs - fluid retention
Fluid retention and edema have been reported in association with the use of nonsteroidal anti-inflammatory drugs (NSAIDs). Therapy with NSAIDs should be administered cautiously in patients with preexisting fluid retention, hypertension, or a history of heart failure. Blood pressure and cardiovascular status should be monitored closely during the initiation of NSAID treatment and throughout the course of therapy.
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- Heerdink ER, Leufkens HG, Herings RM, Ottervanger JP, Stricker BH, Bakker A "NSAIDs associated with increased risk of congestive heart failure in elderly patients taking diuretics." Arch Intern Med 158 (1998): 1108-12
- "Product Information. Lodine (etodolac)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
- "Product Information. Celebrex (celecoxib)." Searle, Chicago, IL.
- Johnson AG, Nguyen TV, Day RO "Do nonsteroidal anti-inflammatory drugs affect blood pressure? A meta-analysis." Ann Intern Med 121 (1994): 289-300
- "Product Information. Nalfon (fenoprofen)." Xspire Pharma, Ridgeland, MS.
- "Product Information. Anaprox (naproxen)." Roche Laboratories, Nutley, NJ.
- "Product Information. Feldene (piroxicam)." Pfizer US Pharmaceuticals, New York, NY.
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- "Product Information. Motrin (ibuprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
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- "Product Information. Mobic (meloxicam)" Boehringer-Ingelheim, Ridgefield, CT.
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- "Product Information. Ansaid (flurbiprofen)." Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Daypro (oxaprozin)." Searle, Skokie, IL.
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- "Product Information. Clinoril (sulindac)." Merck & Co, Inc, West Point, PA.
- "Product Information. Vioxx (rofecoxib)." Merck & Co, Inc, West Point, PA.
- "Product Information. Naprosyn (naproxen)." Syntex Laboratories Inc, Palo Alto, CA.
- "Product Information. Indocin (indomethacin)." Merck & Co, Inc, West Point, PA.
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- "Product Information. Bextra (valdecoxib)." Pharmacia Corporation, Peapack, NJ.
- "Product Information. Relafen (nabumetone)." SmithKline Beecham, Philadelphia, PA.
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- "Product Information. Tolectin (tolmetin)." McNeil Pharmaceutical, Raritan, NJ.
High Blood Pressure (Hypertension)
Moderate Potential Hazard, Moderate plausibility
NSAIDs - hypertension
NSAIDs including topicals can lead to the onset of new hypertension or worsening of preexisting hypertension, either of which can contribute to the increased incidence of cardiovascular events. Blood pressure should be monitored closely during NSAID therapy and throughout the course of therapy.
Motrin IB (ibuprofen) drug Interactions
There are 455 drug interactions with Motrin IB (ibuprofen)
Motrin IB (ibuprofen) disease Interactions
There are 13 disease interactions with Motrin IB (ibuprofen) which include:
- Fluid Retention
- Gi Toxicity
- Renal Toxicities
- Heart Failure
- Platelet Aggregation Inhibition
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No information available.|
Do not stop taking any medications without consulting your healthcare provider.
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