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Difil G (dyphylline / guaifenesin) and Alcohol / Food Interactions

There is 1 alcohol/food/lifestyle interaction with Difil G (dyphylline / guaifenesin):


High Blood Pressure (Hypertension)

Moderate Potential Hazard, Moderate plausibility

dyphylline - cardiotoxicity

Like other methylxanthines, dyphylline at high dosages may be associated with positive inotropic and chronotropic effects on the heart. Therapy with dyphylline and products containing dyphylline should be administered cautiously in patients with severe cardiac disease, hypertension, hyperthyroidism, or recent myocardial infarction. The relationship between plasma dyphylline levels and therapeutic as well as toxic effects has not been determined.


  1. "Multum Information Services, Inc. Expert Review Panel"
  2. "Product Information. Lufyllin (dyphylline)" Wallace Laboratories, Cranbury, NJ.

Difil G (dyphylline / guaifenesin) drug interactions

There are 128 drug interactions with Difil G (dyphylline / guaifenesin)

Difil G (dyphylline / guaifenesin) disease interactions

There are 4 disease interactions with Difil G (dyphylline / guaifenesin) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.