Dibent and Alcohol/Food Interactions
There are 2 alcohol/food/lifestyle interactions with Dibent (dicyclomine).
dicyclomine Alcohol (Ethanol)
Moderate Drug Interaction
GENERALLY AVOID: Use of anticholinergic agents with alcohol may result in sufficient impairment of attention so as to render driving and operating machinery more hazardous. In addition, the potential for abuse may be increased with the combination. The mechanism of interaction is not established but may involve additive depressant effects on the central nervous system. No effect of oral propantheline or atropine on blood alcohol levels was observed in healthy volunteers when administered before ingestion of a standard ethanol load. However, one study found impairment of attention in subjects given atropine 0.5 mg or glycopyrrolate 1 mg in combination with alcohol.
MANAGEMENT: Alcohol should generally be avoided during therapy with anticholinergic agents. Patients should be counseled to avoid activities requiring mental alertness until they know how these agents affect them.
References
- Linnoila M "Drug effects on psychomotor skills related to driving: interaction of atropine, glycopyrrhonium and alcohol." Eur J Clin Pharmacol 6 (1973): 107-12
High Blood Pressure (Hypertension)
Minor Potential Hazard, Moderate plausibility
anticholinergics - hypertension
Cardiovascular effects of anticholinergics may exacerbate hypertension. Therapy with anticholinergic agents should be administered cautiously in patients with hypertension.
References
- "Product Information. Benadryl (diphenhydramine)." Parke-Davis PROD (2002):
- "Product Information. Antivert (meclizine)." Roerig Division PROD (2001):
- "Product Information. Marezine (cyclizine)." Glaxo Wellcome PROD (2001):
- Valentin N, Staffeldt H, Kyst A "Effect of i.v. atropine on cardiac rhythm, heart rate, blood pressure and airway secretion during isoflurane anaesthesia." Acta Anaesthesiol Scand 28 (1984): 621-4
- "Product Information. Atropine Sulfate (atropine)." ESI Lederle Generics (2022):
- "Product Information. Artane (trihexyphenidyl)." Lederle Laboratories PROD (2001):
- "Product Information. Atropisol (atropine ophthalmic)." Ciba Vision Ophthalmics (2002):
Dibent drug interactions
There are 205 drug interactions with Dibent (dicyclomine).
Dibent disease interactions
There are 18 disease interactions with Dibent (dicyclomine) which include:
- autonomic neuropathy
- GI obstruction
- glaucoma
- obstructive uropathy
- tardive dyskinesia
- myasthenia gravis
- infectious diarrhea
- CV acute hemorrhage
- reflux esophagitis.
- severe ulcerative colitis
- coronary artery disease
- gastroesophageal reflux
- psychoses
- hepatic impairment
- hyperthyroidism
- renal impairment
- hypertension
- fever
More about Dibent (dicyclomine)
- Check interactions
- Compare alternatives
- Side effects
- Dosage information
- During pregnancy
- Drug class: anticholinergics/antispasmodics
- Breastfeeding
Related treatment guides
Drug Interaction Classification
Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.