Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine) and Alcohol / Food Interactions
There is 1 alcohol/food/lifestyle interaction with Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine):
phenylpropanolamine ↔ food
Moderate Food Interaction
Consumer information for this interaction is not currently available.
GENERALLY AVOID: Alcohol may potentiate the central nervous system and cardiovascular effects of centrally-acting appetite suppressants. In one study, concurrent administration of methamphetamine (30 mg intravenously) and ethanol (1 gm/kg orally over 30 minutes) increased heart rate by 24 beats/minute compared to methamphetamine alone. This increases cardiac work and myocardial oxygen consumption, which may lead to more adverse cardiovascular effects than either agent alone. Subjective effects of ethanol were diminished in the eight study subjects, but those of methamphetamine were not affected. The pharmacokinetics of methamphetamine were also unaffected except for a decrease in the apparent volume of distribution at steady state.
MANAGEMENT: Concomitant use of centrally-acting appetite suppressants and alcohol should be avoided if possible, especially in patients with a history of cardiovascular disease. Patients should be counselled to avoid hazardous activities requiring complete mental alertness and motor coordination until they know how these agents affect them, and to notify their physician if they experience excessive or prolonged CNS effects that interfere with their normal activities.
- Mendelson J, Jones RT, Upton R, Jacob P 3rd "Methamphetamine and ethanol interactions in humans." Clin Pharmacol Ther 57 (1995): 559-68
- "Product Information. Didrex (benzphetamine)" Pharmacia and Upjohn, Kalamazoo, MI.
- "Product Information. Suprenza (phentermine)." Akrimax Pharmaceuticals, Cranford, NJ.
Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine) drug interactions
There are 1056 drug interactions with Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine)
Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine) disease interactions
There are 21 disease interactions with Alphen Expectorant (codeine / guaifenesin / phenylpropanolamine) which include:
- impaired GI motility
- infectious diarrhea
- liver disease
- renal dysfunction
- acute alcohol intoxication
- drug dependence
- intracranial pressure
- respiratory depression
- cardiovascular disease
- adrenal insufficiency
- biliary spasm
- seizure disorders
- urinary retention
Drug Interaction Classification
|Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.|
|Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.|
|Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.|
|No interaction information available.|
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.