Plummer-Vinson syndrome is a condition that can occurs in people with long-term (chronic) iron deficiency anemia. People with this condition have problems swallowing due to small, thin growths of tissue that partially block the upper food pipe (esophagus).
Causes of Plummer-Vinson syndrome
The cause of Plummer-Vinson syndrome is unknown. Genetic factors and a lack of certain nutrients (nutritional deficiencies) may play a role. It is a rare disorder that can be linked to cancers of the esophagus and throat. It is more common in women.
Plummer-Vinson syndrome Symptoms
Symptoms may include:
- Difficulty swallowing
Tests and Exams
Your doctor will do an exam to look for abnormal areas on your skin and nails.
Treatment of Plummer-Vinson syndrome
Taking iron supplements may improve the swallowing problems.
If supplements do not help, the web of tissue can be widened during upper endoscopy. This will allow you to swallow food normally.
People with this condition generally respond to treatment.
Devices used to stretch the esophagus (dilators) may cause a tear. This can lead to bleeding.
Plummer-Vinson syndrome has been linked to esophageal cancer.
When to Contact a Health Professional
Call your health care provider if:
- Food gets stuck after you swallow it
- You have severe fatigue and weakness
Prevention of Plummer-Vinson syndrome
Getting enough iron in your diet may prevent this disorder.
Long JD, Orlando RC. Anatomy, histology, embryology, and developmental anomalies of the esophagus. In: Feldman M, Friedman LS, Brandt LJ, eds. Sleisenger and Fordtran's Gastrointestinal and Liver Disease. 9th ed. Philadelphia, PA: Elsevier Saunders; 2010:chap 41.
|Review Date: 11/20/2014
Reviewed By: Jenifer K. Lehrer, MD, Department of Gastroenterology, Frankford-Torresdale Hospital, Aria Health System, Philadelphia, PA. Review provided by VeriMed Healthcare Network. Also reviewed by David Zieve, MD, MHA, Isla Ogilvie, PhD, and the A.D.A.M. Editorial team.