Alternative Names: Blood urea nitrogen
A test can be done to measure the amount of urea nitrogen in the blood.
Why is the Test Performed?
The BUN test is often done to check kidney function.
How is the Test Performed?
Blood is typically drawn from a vein, usually from the inside of the elbow or the back of the hand. The site is cleaned with germ-killing medicine (antiseptic). The health care provider wraps an elastic band around the upper arm to apply pressure to the area and make the vein swell with blood.
Next, the health care provider gently inserts a needle into the vein. The blood collects into an airtight vial or tube attached to the needle. The elastic band is removed from your arm.
Once the blood has been collected, the needle is removed, and the puncture site is covered to stop any bleeding.
In infants or young children, a sharp tool called a lancet may be used to puncture the skin and make it bleed. The blood collects into a small glass tube called a pipette, or onto a slide or test strip. A bandage may be placed over the area if there is any bleeding.
Preparation for the Test
Many drugs affect BUN levels. Before having this test, make sure the health care provider knows which medications you are taking.
Drugs that can increase BUN measurements include:
- Amphotericin B
- Aspirin (high doses)
- Chloral hydrate
- Polymyxin B
- Thiazide diuretics
Drugs that can decrease BUN measurements include:
How will the Test Feel?
When the needle is inserted to draw blood, some people feel moderate pain, while others feel only a prick or stinging sensation. Afterward, there may be some throbbing.
Veins and arteries vary in size from one patient to another and from one side of the body to the other. Obtaining a blood sample from some people may be more difficult than from others.
Other risks are slight but may include:
- Excessive bleeding
- Fainting or feeling light-headed
- Hematoma (blood accumulating under the skin)
- Infection (a slight risk any time the skin is broken)
For people with liver disease, the BUN level may be low even if the kidneys are normal.
Normal Results for BUN
7 - 20 mg/dL. Note that normal values may vary among different laboratories.
What Abnormal Results Mean
Higher-than-normal levels may be due to:
- Congestive heart failure
- Excessive protein levels in the gastrointestinal tract
- Gastrointestinal bleeding
- Heart attack
- Kidney disease, including glomerulonephritis, pyelonephritis, and acute tubular necrosis
- Kidney failure
- Urinary tract obstruction
Lower-than-normal levels may be due to:
- Liver failure
- Low protein diet
Additional conditions under which the test may be done include:
- Acute nephritic syndrome
- Alport syndrome
- Atheroembolic kidney disease
- Dementia due to metabolic causes
- Diabetic nephropathy/sclerosis
- Digitalis toxicity
- Generalized tonic-clonic seizure
- Goodpasture syndrome
- Hemolytic-uremic syndrome (HUS)
- Hepatokidney syndrome
- Interstitial nephritis
- Lupus nephritis
- Malignant hypertension (arteriolar nephrosclerosis)
- Medullary cystic kidney disease
- Membranoproliferative GN I
- Membranoproliferative GN II
- Type 2 diabetes
- Prerenal azotemia
- Primary amyloidosis
- Secondary systemic amyloidosis
- Wilms' tumor
Reviewed By: David C. Dugdale, III, MD, Professor of Medicine, Division of General Medicine, Department of Medicine, University of Washington School of Medicine; Jatin M. Vyas, MD, PhD, Assistant Professor in Medicine, Harvard Medical School, Assistant in Medicine, Division of Infectious Disease, Department of Medicine, Massachusetts General Hospital. Also reviewed by David Zieve, MD, MHA, Medical Director, A.D.A.M., Inc.
Copyright 2011 A.D.A.M., Inc.