Acquired platelet function defect
Acquired platelet function defects are conditions that prevent clotting elements in the blood called platelets from working as they should. The term "acquired" means these conditions are not present at birth.
Causes of Acquired platelet function defect
With platelet disorders can affect the number of platelets, how well they function, or both. Any platelet disorder affects normal blood clotting.
Disorders that can cause problems in platelet function include:
Other causes include:
- Kidney (renal) failure
- Multiple myeloma
- Medicines such as aspirin, ibuprofen and other anti-inflammatory drugs, penicillins, phenothiazines, and prednisone (after long-term use)
Acquired platelet function defect Symptoms
- Abnormal menstrual periods
- Heavy menstrual periods
- Prolonged menstrual bleeding (more than 5 days per menstrual period)
- Abnormal vaginal bleeding
- Bleeding in the urine
- Bleeding under the skin or in the muscles (soft tissues)
- Gastrointestinal bleeding
- Prolonged bleeding, easy bruising
- Skin rash
- Pinpoint red spots (petechiae)
Tests and Exams
Treatment of Acquired platelet function defect
Treatment is aimed at the cause of the problem.
- Bone marrow disorders are treated with platelet transfusions or removing platelets from the blood (platelet pheresis). Chemotherapy is can used to treat an underlying condition that is causing the problem.
- Platelet function defects caused by kidney failure are treated with dialysis or a drug called desmopressin (ddAVP).
- Platelet problems caused by a certain medicine are treated by stopping the drug.
Most of the time, treating the cause of the problem corrects the defect.
- Prolonged bleeding
- Severe anemia
When to Contact a Health Professional
Call your health care provider if:
- You have bleeding and do not know the cause
- Your symptoms get worse
- Your symptoms do not improve after you are treated for an acquired platelet function defect
Prevention of Acquired platelet function defect
Using medicines as directed can reduce the risk of drug-related acquired platelet function defects. Treating other disorders may also reduce the risk. Some cases cannot be prevented.
Diz-Kucukkaya R, Lopez JA, Acquired disorders of platelet function. In: Hoffman R, Benz EJ Jr, Silberstein LE, Heslop HE, Weitz JI, eds. Hematology: Basic Principles and Practice. 6th ed. Philadelphia, PA: Saunders Elsevier; 2012:chap 132.
Ragni MV. Hemorrhagic Disorders: Coagulation Factor Deficiencies. In: Goldman L, Schafer AI, eds. Goldman's Cecil Medicine. 24th ed. Philadelphia, PA: Saunders Elsevier; 2011:chap 177.
|Review Date: 3/3/2013
Reviewed By: Yi-Bin Chen, MD, Leukemia/Bone Marrow Transplant Program, Massachusetts General Hospital. Also reviewed by A.D.A.M. Health Solutions, Ebix, Inc., Editorial Team: David Zieve, MD, MHA, Bethanne Black, Stephanie Slon, and Nissi Wang.