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Morphine Injections

Last Updated: January 6, 2018
Status: Current

Morphine Injections

Products Affected - Description
  • Morphine injection, Fresenius Kabi
    2 mg/mL, 1 mL preservative-free prefilled syringe, 24 count (NDC 76045-0004-10)

4 mg/mL, 1 mL preservative-free prefilled syringe, 24 count (NDC 76045-0005-10)
5 mg/mL, 1 mL preservative-free prefilled syringe, 24 count (NDC 76045-0006-10)
8 mg/mL, 1 mL preservative-free prefilled syringe, 24 count (NDC 76045-0007-10)
10 mg/mL, 1 mL preservative-free prefilled syringe, 24 count (NDC 76045-0008-10)
 
Morphine injection, Pfizer
0.5 mg/mL, 10 mL preservative-free vial, 25 count (NDC 00409-3814-12)
1 mg/mL, 10 mL preservative-free vial, 25 count (NDC 00409-3815-12)
2 mg/mL, 1 mL preservative-free Carpuject syringe, 10 count (NDC 00409-1890-01)
2 mg/mL, 1 mL preservative-free iSecure syringe, 10 count (NDC 00409-1890-11)
4 mg/mL, 1 mL preservative-free Carpuject syringe, 10 count (NDC 00409-1891-01)
4 mg/mL, 1 mL preservative-free iSecure syringe, 10 count (NDC 00409-1891-11)
8 mg/mL, 1 mL preservative-free Carpuject syringe, 10 count (NDC 00409-1892-01
8 mg/mL, 1 mL preservative-free iSecure syringe, 10 count (NDC 00409-1892-11)
10 mg/mL, 1 mL preservative-free Carpuject syringe, 10 count (NDC 00409-1893-01)
10 mg/mL, 1 mL preservative-free iSecure syringe, 10 count (NDC 00409-1893-11)
25 mg/mL, 1 mL preservative-free vial, 50 count (NDC 00409-1135-02)
50 mg/mL, 50 mL vial, 50 count (NDC 00409-1134-05)
 
Morphine injection, West-Ward
4 mg/mL, 1 mL vial, 25 count (NDC 00641-6125-25)
8 mg/mL, 1 mL vial, 25 count (NDC 00641-6126-25)
10 mg/mL, 1 mL vial, 25 count (NDC 00641-6127-25)
Reason for the Shortage
    • Astramorph injection has been unavailable since 2012. Fresenius Kabi changed manufacturing sites and cannot estimate if Astramorph will return.
    • Pfizer states the shortage is due to manufacturing delays. Pfizer discontinued morphine ADD-Vantage vials in January 2017.
    • Pfizer anticipates a shortage of several prefilled syringe products, including morphine, starting in late-July 2017 due to issues at a manufacturing facility. To minimize the impact of the shortage, Pfizer is prioritizing production of certain morphine Carpuject syringes. Pfizer expects the shortage of prefilled syringe products to recover by late-first quarter 2018.
    • West-Ward launched several new morphine sulfate products in late-September 2015. They are not actively marketing the 15 mg/mL 1 mL vials or the 8 mg/mL 1 mL vials (NDC 00641-6075-25). They are still marketing the 8 mg/mL 1 mL vials with NDC 00641-6126-25.
Available Products
  • Duramorph (preservative-free) injection, West-Ward
    0.5 mg/mL, 10 mL ampule, 10 count (NDC 00641-6020-10)
    1 mg/mL, 10 mL ampule, 10 count (NDC 00641-6019-10)

 
Infumorph (preservative-free) injection, West-Ward
10 mg/mL, 20 mL ampule, 1 count (NDC 00641-6039-01)
25 mg/mL, 20 mL ampule, 1 count (NDC 00641-6040-01)
 
Morphine injection, Pfizer
50 mg/mL, 20 mL vial, 50 count (NDC 00409-1134-03)

Estimated Resupply Dates

    • Fresenius Kabi has morphine 2 mg/mL 1 mL syringes and 4 mg/mL 1 mL syringes on intermittent back order and the company is releasing product as it becomes available. The morphine 5 mg/mL 1 mL syringes are on back order and the company estimates a release date of 1st quarter 2018. The morphine 8 mg/mL and 10 mg/mL 1 mL syringes are on back order and the company cannot estimate a release date.
    • Pfizer has morphine 2 mg/mL 1 mL Carpuject syringes on back order and the company estimates a release date of early-February 2018. The 4 mg/mL 1 mL Carpuject syringes are on back order and the company estimates a release date of mid-February 2018. The 50 mg/mL 50 mL vials are on back order and the company estimates a release date of mid-January 2018. The 0.5 mg/mL 10 mL preservative-free vials are available in limited supply. The 25 mg/mL 1 mL preservative-free vials are available in limited supply. The 1 mg/mL 10 mL preservative-free vials are on back order and the company estimates a release date of late-January 2018. The 2 mg/mL 1 mL iSecure syringes, 4 mg/mL 1 mL iSecure syringes, 8 mg/mL 1 mL Carpuject syringes, 8 mg/mL 1 mL iSecure syringes, 10 mg/mL 1 mL iSecure syringes, and 10 mg/mL 1 mL Carpuject syringes are on back order and the company estimates a release date of June 2019.
    • West-Ward has morphine 4 mg/mL 1 mL vials and 10 mg/mL 1 mL vials on back order and the company estimates a release date of January 2018. The morphine 8 mg/mL 1 mL vials are on allocation.

Updated

January 6, 2018; December 29, 18, 11 and 6, November 29, 16 and 2, October 4, September 26, 11 and 6, August 11, July 31, 25, 14 and 7, June 21, 9 and 8, May 5, March 1, January 27, 2017; December 19, November 10, October 8, September 7, August 25, June 23, May 25, April 11, February 24, January 29, 2016; December 17, November 17, October 19, September 30, December 22, November 14, October 31, September 23,  September 3, August 14, July 12, June 19, April 25, March 21, February 6, January 23, 2013; December 2, November 11, October 21, September 16, June 23, 2009, University of Utah, Drug Information Service. Copyright 2017, Drug Information Service, University of Utah, Salt Lake City, UT.

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