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Digoxin Immune Fab

Last Updated: March 28, 2018
Status: Resolved

Multiple Electrolytes Large Volume Solutions For Injection

Products Affected - Description
    • Plasma-Lyte 148 solution for injection, Baxter, 1,000 mL bag, NDC 00338-0179-04
    • Plasma-Lyte 148 solution for injection, Baxter, 500 mL bag, NDC 00338-0179-03
    • Plasma-Lyte A solution for injection, Baxter, 500 mL bag, NDC 00338-0221-03
Reason for the Shortage
    • Baxter did not provide a reason for Plasma-Lyte 148 and Plasma-Lyte A back order.
    • Pfizer had Normosol-R presentations on back order due to manufacturing delays.
Available Products
    • Normosol-R solution for injection, ICU Medical, 1000 mL bag, NDC 00409-7967-09
    • Normosol-R pH 7.4 solution for injection, ICU Medical, 1,000 mL bag, NDC 00409-7670-09
    • Normosol-R pH 7.4 solution for injection, ICU Medical, 500 mL bag, NDC 00409-7670-03
    • Plasma-Lyte A solution for injection, Baxter, 1,000 mL bag, NDC 00338-0221-04

Estimated Resupply Dates

    • Baxter has Plasma-Lyte-148 500 mL and 1,000 mL bags and Plasma-Lyte-A 500 mL bags available in limited quantities.

Alternative Agents & Management

  • Table 1. Comparison of Multiple Electrolytes Large Volume Solutions for Injection1-4

    Plasma-Lyte 148
    Plasma-Lyte-A
    (nonpyrogenic, isotonic)
    Normosol-R
    Contents (per 100 mL) Sodium chloride - 526 mg
    Sodium gluconate - 502 mg
    Sodium acetate trihydrate - 368 mg
    Potassium chloride - 37 mg
    Magnesium chloride - 30 mg
    Sodium chloride - 526 mg
    Sodium gluconate - 502 mg
    Sodium acetate - 222 mg
    Potassium chloride - 37 mg
    Magnesium chloride, hexahydrate - 30 mg
    Ionic concentrations (per 1 L) Sodium - 140 mEq
    Potassium - 5 mEq
    Magnesium - 3 mEq
    Chloride - 98 mEq
    Acetate - 27 mEq
    Gluconate - 23 mEq
    Sodium - 140 mEq
    Potassium - 5 mEq
    Magnesium - 3 mEq
    Chloride - 98 mEq
    Acetate - 27 mEq
    Gluconate - 23 mEq
    Osmolarity 294 mOsmol/L 294 - 295 mOsmol/L
    pH 5.5 (Plasma-Lyte 148)
    7.4 (Plasma-Lyte-A)
    6.6 (Normosol-R)
    7.4 (Normosol-R pH 7.4)
    Caloric content 21 kcal/L Not specified in package insert
    Labeled indications Source of water and electrolytes
    Alkalinizing agent
    Replacement of acute extracellular fluid volume losses in surgery, trauma, burns, or shock
    Adjunct to restore decreased circulatory volume

References

    1. Plasma-Lyte 148 [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
    2. Plasma-Lyte A [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
    3. Normosol-R [package insert]. Lake Forest, IL: Hospira; 2009.
    4. Normosol-R pH 7.4 [package insert]. Lake Forest, IL: Hospira; 2009.

Updated

Updated March 28, 2018 by Leslie Jensen, PharmD, Drug Information Specialist. Created February 1, 2018 by Elyse MacDonald, PharmD, MS, BCPS. Copyright 2018, Drug Information Service, University of Utah, Salt Lake City, UT.

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