Multiple Electrolytes Large Volume Solutions for Injection Shortage

• • Baxter has Plasma-Lyte 148 and Plasma-Lyte A presentations available.
  • ICU Medical had Normosol-R presentations on back order due to manufacturing delays.

• • Normosol-R solution for injection, ICU Medical, 1000 mL bag, NDC 00409-7967-09
  • Normosol-R pH 7.4 solution for injection, ICU Medical, 1,000 mL bag, NDC 00409-7670-09
  • Normosol-R pH 7.4 solution for injection, ICU Medical, 500 mL bag, NDC 00409-7670-03
  • Plasma-Lyte 148 solution for injection, Baxter, 1,000 mL bag, NDC 00338-0179-04
  • Plasma-Lyte 148 solution for injection, Baxter, 500 mL bag, NDC 00338-0179-03
  • Plasma-Lyte A solution for injection, Baxter, 1,000 mL bag, NDC 00338-0221-04
  • Plasma-Lyte A solution for injection, Baxter, 500 mL bag, NDC 00338-0221-03

Alternative Agents & Management

• Table 1. Comparison of Multiple Electrolytes Large Volume Solutions for Injection1-4

  	Plasma-Lyte 148 Plasma-Lyte-A (nonpyrogenic, isotonic)	Normosol-R
  Contents (per 100 mL)	Sodium chloride - 526 mg Sodium gluconate - 502 mg Sodium acetate trihydrate - 368 mg Potassium chloride - 37 mg Magnesium chloride - 30 mg	Sodium chloride - 526 mg Sodium gluconate - 502 mg Sodium acetate - 222 mg Potassium chloride - 37 mg Magnesium chloride, hexahydrate - 30 mg
  Ionic concentrations (per 1 L)	Sodium - 140 mEq Potassium - 5 mEq Magnesium - 3 mEq Chloride - 98 mEq Acetate - 27 mEq Gluconate - 23 mEq	Sodium - 140 mEq Potassium - 5 mEq Magnesium - 3 mEq Chloride - 98 mEq Acetate - 27 mEq Gluconate - 23 mEq
  Osmolarity	294 mOsmol/L	294 - 295 mOsmol/L
  pH	5.5 (Plasma-Lyte 148) 7.4 (Plasma-Lyte-A)	6.6 (Normosol-R) 7.4 (Normosol-R pH 7.4)
  Caloric content	21 kcal/L	Not specified in package insert
  Labeled indications	Source of water and electrolytes Alkalinizing agent	Replacement of acute extracellular fluid volume losses in surgery, trauma, burns, or shock Adjunct to restore decreased circulatory volume

  
  

References

• 1. Plasma-Lyte 148 [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
  2. Plasma-Lyte A [package insert]. Deerfield, IL: Baxter Healthcare; 2017.
  3. Normosol-R [package insert]. Lake Forest, IL: Hospira; 2009.
  4. Normosol-R pH 7.4 [package insert]. Lake Forest, IL: Hospira; 2009.