Bupivacaine Hydrochloride Injection Shortage

Last Updated: September 5, 2025
Status: Current

Unavailable, Current:

• Bupivacaine Hydrochloride, Injection, 0.25%; 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 125 mg/50 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)
• Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)

Limited Availability, Current:

• Marcaine, Injection, 0.75% 15 mg/2 mL (7.5 mg/mL) in Dextrose 8.25% (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 150 mg/30 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 25 mg/10 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 75 mg/10 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)

Available, Current:

• Bupivacaine Hydrochloride, Injection, 125 mg/50 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Eugia US LLC)
• Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)
• Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Somerset Therapeutics, LLC)
• Bupivacaine Hydrochloride, Injection, 225 mg/30 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 25 mg/10 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 250 mg/50 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Eugia US LLC)
• Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)
• Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Somerset Therapeutics, LLC)
• Bupivacaine Hydrochloride, Injection, 50 mg/10 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Eugia US LLC)
• Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Huons Co., Ltd)
• Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)
• Bupivacaine Hydrochloride, Injection, 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Bupivacaine Hydrochloride, Injection, Bupivacaine Spinal 15 mg/2 mL (7.5 mg/mL in 8.25% dextrose) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, 0.75% 15 mg/2 mL (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 225 mg/30 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 250 mg/50 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 50 mg/10 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, Marcaine 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)
• Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)
• Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)
• Sensorcaine, Injection, 7.5 mg/1 mL (Fresenius Kabi USA, LLC)

Limited Available, Current:

• Bupivacaine Hydrochloride, Injection, 150 mg/30 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

To Be Discontinued:

• Bupivacaine Hydrochloride, Injection, 0.25%; 75 mg/30 mL (2.5 mg/mL); 30 mL Single Dose Glass Teartop Vial NOVAPLUS (Hospira, Inc., a Pfizer Company)
• Marcaine, Injection, 250 mg/50 mL (5 mg/mL); Multiple Dose Glass Fliptop Vial (Hospira, Inc., a Pfizer Company)

Bupivacaine Hydrochloride, Injection, 0.25%; 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1159-10
Availability: Unavailable
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Reason for shortage: Other
Related Information: Next Delivery and Estimated Recovery: December 2028
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 125 mg/50 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1587-50
Availability: Unavailable
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Other
Related Information: Next Delivery: August 2025; Estimated Recovery: December 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-464-31
Availability: Unavailable
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Reason for shortage: Demand increase for the drug
Related Information: Not available at this time.
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-466-31
Availability: Unavailable
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Reason for shortage: Delay in shipping of the drug
Related Information: Not available at this time.
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Marcaine, Injection, 0.75% 15 mg/2 mL (7.5 mg/mL) in Dextrose 8.25% (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1761-10
Availability: Limited Availability
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Other
Related Information: Limited Supply Available. Next Delivery: October 2025; Estimated Recovery: December 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 150 mg/30 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1560-29
Availability: Limited Availability
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Other
Related Information: Limited Supply Available. Next Delivery: August 2025; Estimated Recovery: December 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 25 mg/10 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1559-10
Availability: Limited Availability
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Demand increase for the drug
Related Information: Limited Supply Available. Next Delivery and Estimated Recovery: December 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 75 mg/10 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1582-10
Availability: Limited Availability
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Other
Related Information: Limited Supply Available. Next Delivery: August 2025; Estimated Recovery: December 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 125 mg/50 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1160-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 150 mg/30 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1162-02
Availability: Limited Available
Status: Current
Date of update: August 15, 2025
Update type: Revised
Reason for shortage: Other
Related Information: Limited Supply Available. Next Delivery: August 2025; Estimated Recovery: September 2025
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)

NDC Code: 71288-723-52
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Related Information: Meitheal Pharmaceuticals is distributor/labeler; product is available
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-824-8426

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)

NDC Code: 71288-722-32
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Related Information: Meitheal Pharmaceuticals is distributor/labeler; product is available
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-824-8426

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Somerset Therapeutics, LLC)

NDC Code: 70069-752-25
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 732-554-1037

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-167-10
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-168-30
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 2.5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-249-50
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 225 mg/30 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1165-02
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 25 mg/10 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1159-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 250 mg/50 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1163-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)

NDC Code: 71288-726-52
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Related Information: Meitheal Pharmaceuticals is distributor/labeler; product is available
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-824-8426

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)

NDC Code: 71288-725-32
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Related Information: Meitheal Pharmaceuticals is distributor/labeler; product is available
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-824-8426

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Somerset Therapeutics, LLC)

NDC Code: 70069-753-25
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 732-554-1037

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-169-10
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-170-30
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-250-50
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 50 mg/10 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1162-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Kindos Pharmaceuticals Co. Ltd.)

NDC Code: 71288-728-32
Availability: Available
Status: Current
Date of update: August 19, 2025
Update type: Reverified
Related Information: Meitheal Pharmaceuticals is distributor/labeler; product is available
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-824-8426

Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-171-10
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Eugia US LLC)

NDC Code: 55150-172-30
Availability: Available
Status: Current
Date of update: September 5, 2025
Update type: Revised
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-238-7880

Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1165-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, 7.5 mg/1 mL (Huons Co., Ltd)

NDC Code: 73293-0002-2
Availability: Available
Status: Current
Date of update: June 27, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: +82-2-854-4700 or via email intbiz@huons.com

Bupivacaine Hydrochloride, Injection, 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1159-02
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Bupivacaine Hydrochloride, Injection, Bupivacaine Spinal 15 mg/2 mL (7.5 mg/mL in 8.25% dextrose) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-3613-01
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, 0.75% 15 mg/2 mL (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1761-62
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Analgesia/Addiction
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 225 mg/30 mL (7.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1582-29
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 250 mg/50 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1610-50
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 50 mg/10 mL (5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1560-10
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Marcaine, Injection, Marcaine 75 mg/30 mL (2.5 mg/mL) (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1559-30
Availability: Available
Status: Current
Date of update: August 15, 2025
Update type: Reverified
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 844-646-4398

Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-465-57
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-464-17
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 2.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-464-37
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-467-57
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-466-17
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-466-37
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 7.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-472-17
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Sensorcaine, Injection, 7.5 mg/1 mL (Fresenius Kabi USA, LLC)

NDC Code: 63323-472-37
Availability: Available
Status: Current
Date of update: September 2, 2025
Update type: Reverified
Related Information: Check wholesalers for inventory
Therapeutic category: Anesthesia
Initial posting date: February 20, 2018
Contact info: 888-386-1300

Bupivacaine Hydrochloride, Injection, 0.25%; 75 mg/30 mL (2.5 mg/mL); 30 mL Single Dose Glass Teartop Vial NOVAPLUS (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1159-10
Status: To Be Discontinued
Date of update: January 10, 2025
Update type: New
Related Information: Discontinuation of the manufacture of the drug
Therapeutic category: Anesthesia
Date discontinued: January 10, 2025
Initial posting date: January 10, 2025
Contact info: 844-646-4398

Marcaine, Injection, 250 mg/50 mL (5 mg/mL); Multiple Dose Glass Fliptop Vial (Hospira, Inc., a Pfizer Company)

NDC Code: 0409-1610-50
Status: To Be Discontinued
Date of update: January 10, 2025
Update type: New
Related Information: Discontinuation of the manufacture of the drug. Replaced with NDC 0409-0525-01
Therapeutic category: Anesthesia
Date discontinued: January 10, 2025
Initial posting date: January 10, 2025
Contact info: 844-646-4398

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