Skip to main content

Drug Interactions between tovorafenib and Zurzuvae

This report displays the potential drug interactions for the following 2 drugs:

Edit list (add/remove drugs)

Interactions between your drugs

Moderate

zuranolone tovorafenib

Applies to: Zurzuvae (zuranolone) and tovorafenib

Consumer information for this interaction is not currently available.

GENERALLY AVOID: Coadministration of zuranolone with CYP450 3A4 inducers may significantly reduce the plasma concentrations and systemic effects of zuranolone. The proposed mechanism is induction of the CYP450 3A4-mediated metabolism of zuranolone, which is primarily metabolized by this isoenzyme. Drug interaction studies have shown that coadministration with the potent CYP450 3A4 inducer rifampin decreased the systemic exposure (AUC) and peak plasma concentration (Cmax) by approximately 80% and 70%, respectively. However, data for less potent CYP450 3A4 inducers are lacking.

MANAGEMENT: Until further information is available, concomitant use of zuranolone with CYP450 3A4 inducers should generally be avoided. If coadministration is required, the possibility of diminished therapeutic response to zuranolone should be considered. Pharmacologic response to zuranolone should be monitored more closely whenever a CYP450 3A4 inducer is added to or withdrawn from therapy.

References

  1. (2023) "Product Information. Zurzuvae (zuranolone)." Biogen Inc.

Drug and food interactions

Moderate

zuranolone food

Applies to: Zurzuvae (zuranolone)

Zuranolone must be taken with fat-containing food to ensure adequate absorption of the mediation. It is also best to avoid or limit the consumption of alcohol, as it can increase drowsiness or other nervous system side effects of zuranolone. You should also avoid activities requiring mental alertness such as driving or operating hazardous machinery until at least 12 hours after taking zuranolone. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

Switch to professional interaction data

Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

Report options

Loading...
QR code containing a link to this page

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Medical Disclaimer