Skip to Content

Epclusa (sofosbuvir / velpatasvir) Drug Interactions

A total of 186 drugs are known to interact with Epclusa (sofosbuvir / velpatasvir).

  • 57 major drug interactions
  • 123 moderate drug interactions
  • 6 minor drug interactions

Show all medications in the database that may interact with Epclusa (sofosbuvir / velpatasvir).

Check for interactions

Type in a drug name to check for interactions with Epclusa (sofosbuvir / velpatasvir).

Most frequently checked interactions

View interaction reports for Epclusa (sofosbuvir / velpatasvir) and the medicines listed below.

  • albuterol (Ventolin, Ventolin HFA, ProAir HFA, Proventil, Proventil HFA, ProAir RespiClick, AccuNeb, Respirol, Vospire ER, Volmax, ProAir Digihaler, Airet)
  • amlodipine (Norvasc)
  • aspirin (Aspir 81, Ecotrin, Aspirin Low Strength, Acetylsalicylic Acid, Bayer Aspirin, Aspir-Low, Bufferin, Ascriptin, Arthritis Pain, Aspiritab, Aspergum, Fasprin, Halfprin, Easprin, Ecotrin Adult Low Strength, Empirin, Migralex, Aspi-Cor, St. Joseph 81 mg Chewable Aspirin, Bayer Children's Aspirin, Buffered Aspirin, Durlaza, Ecotrin Maximum Strength, Entercote, Bufferin Extra Strength, Ascriptin Enteric, St. Joseph 81 mg Aspirin Enteric Safety-Coated, Bayer Aspirin Regimen, Ascriptin Maximum Strength, Arthritis Foundation Pain Reliever, Bayer Aspirin with Heart Advantage, Aspirtab, Bufferin Low Dose, Medi-Seltzer, Sloprin, ZORprin, Low Dose ASA, Bayer Aspirin Extra Strength Plus, Buffex, Extra Strength Bayer, Genacote, Gennin-FC, Genprin, Litecoat Aspirin, Minitabs, Tri-Buffered Aspirin, Entaprin, Bufferin Arthritis Strength, Therapy Bayer, St. Joseph Aspirin, Stanback Analgesic, Norwich Aspirin, Acuprin 81, Ecpirin, Bayer Women's Aspirin With Calcium, Zero-Order Release, YSP Aspirin, Miniprin, Aspirin Lite Coat, Heartline, Bayer Advanced Aspirin, Buffasal)
  • bupropion (Wellbutrin, Wellbutrin XL, Wellbutrin SR, Zyban, Buproban, Budeprion, Aplenzin, Forfivo XL, Budeprion XL, Budeprion SR)
  • caffeine (Vivarin, Stay Awake, NoDoz, Jet Alert Regular Strength, Jet Alert Maximum Strength, Caffedrine, Alert, Diurex Ultra, Cafcit, Jet Alert Double Strength, ConRx Alert, Pep-Back ReCharge, Pep-Back Peak Performance, Keep Alert, Verv, Stat Awake, Stay Alert, NoDoz Maximum Strength, Wakespan, Lucidex, Diurex Maximum Relief Water Caps, Pep-Back Ultra, 357 HR Magnum, Enerjets, Fastlene, Keep Going, Molie, Overtime, Valentine)
  • carvedilol (Coreg, Coreg CR)
  • Cipro (ciprofloxacin)
  • cyclobenzaprine (Flexeril, Amrix, Fexmid, Comfort Pac with Cyclobenzaprine)
  • furosemide (Lasix, Diaqua-2, Lo-Aqua)
  • gabapentin (Neurontin, Gralise, Gabarone, Fanatrex)
  • Humalog (insulin lispro)
  • ibuprofen (Advil, Motrin, IBU, Children's Motrin, Proprinal, Advil Liqui-Gels, Ibu-8, Motrin IB, Motrin Childrens, Rufen, Childrens Ibuprofen Berry, IBU-200, Ibuprofen PMR, Advil Migraine, Ibu-Tab, Genpril, Menadol, Advil Children's, Midol Maximum Strength Cramp Formula, Motrin Migraine Pain, Addaprin, Motrin Infant Drops, NeoProfen, Caldolor, Motrin Pediatric, Haltran, Midol IB, Saleto-200, Q-Profen, Saleto-400, Saleto-600, Saleto-800, A-G Profen, Nuprin, Advil Junior Strength, Actiprofen, PediaCare Infants' IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-4, PediaCare Children's IB Ibuprofen Pain Reliever/Fever Reducer, Ibu-6, Motrin Junior Strength, Help I Have An Aching Body, Children's ElixSure IB, Advil Infant's Concentrated Drops, Cap-Profen, Advil Film-Coated)
  • levothyroxine (Synthroid, Levoxyl, Tirosint, Levothroid, Eltroxin, Euthyrox, Unithroid, Levothyrox, Eutroxsig, Levo-T, Oroxine, L Thyroxine Roche, Levotabs, Novothyrox, Tirosint-Sol, Levotec, Evotrox)
  • lisinopril (Zestril, Prinivil, Qbrelis)
  • losartan (Cozaar)
  • metformin (Glucophage, Glumetza, Glucophage XR, Fortamet, Riomet)
  • omeprazole (Prilosec, Prilosec OTC, Zegerid (Original Formulation), Omesec)
  • ribavirin (Copegus, Virazole, Moderiba, Rebetol, Ribasphere, RibaTab, RibaPak)
  • spironolactone (Aldactone, CaroSpir)
  • tamsulosin (Flomax)
  • trazodone (Desyrel, Oleptro, Desyrel Dividose)
  • Xifaxan (rifaximin)

Epclusa (sofosbuvir / velpatasvir) disease interactions

There is 1 disease interaction with Epclusa (sofosbuvir / velpatasvir):

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Hide