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Drug Interactions between Sinemet CR and Tegsedi

This report displays the potential drug interactions for the following 2 drugs:

  • Sinemet CR (carbidopa/levodopa)
  • Tegsedi (inotersen)

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Interactions between your drugs

No interactions were found between Sinemet CR and Tegsedi. This does not necessarily mean no interactions exist. Always consult your healthcare provider.

Sinemet CR

A total of 316 drugs are known to interact with Sinemet CR.


A total of 226 drugs are known to interact with Tegsedi.

Drug and food interactions


levodopa food

Applies to: Sinemet CR (carbidopa / levodopa)

Alcohol can increase the nervous system side effects of levodopa such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with levodopa. You may experience reduced effectiveness of levodopa in the presence of foods or enteral (tube) feedings with a high protein content. This may make the symptoms of Parkinson's disease worse. Talk with your doctor or nutrition counselor about the best foods to eat while you are taking this medication. Contact your doctor if your condition changes.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.