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Drug Interactions between rimegepant and Vosevi

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Moderate

velpatasvir voxilaprevir

Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir) and Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Velpatasvir may increase the blood levels of voxilaprevir in some patients. The safety of high levels of voxilaprevir has not been established. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact, or you may need a dose adjustment or more frequent monitoring to safely use both medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

velpatasvir rimegepant

Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir) and rimegepant

Velpatasvir may increase the blood levels of rimegepant. This may increase side effects such as nausea, indigestion, and abdominal pain or discomfort. You should avoid taking another dose of rimegepant within 48 hours if you are also receiving treatment with velpatasvir. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

voxilaprevir rimegepant

Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir) and rimegepant

Voxilaprevir may increase the blood levels of rimegepant. This may increase side effects such as nausea, indigestion, and abdominal pain or discomfort. You should avoid taking another dose of rimegepant within 48 hours if you are also receiving treatment with voxilaprevir. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

voxilaprevir food

Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Food may help the absorption of voxilaprevir. You should take this medication with food as directed.

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Moderate

rimegepant food

Applies to: rimegepant

If you are receiving therapy with rimegepant you may want to avoid the regular consumption of large amounts of grapefruits and grapefruit juice. Grapefruit can raise the levels of rimegepant in your body and lead to increased side effects. If grapefruit or grapefruit juice is consumed along with rimegepant, the manufacturer recommends avoiding a second dose of rimegepant within 48 hours. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

See also

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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