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Drug Interactions between rifampin and Vosevi

This report displays the potential drug interactions for the following 2 drugs:

  • rifampin
  • Vosevi (sofosbuvir/velpatasvir/voxilaprevir)

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Interactions between your drugs

Major

rifAMPin sofosbuvir

Applies to: rifampin and Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Using sofosbuvir together with rifAMPin is not recommended. Combining these medications may significantly reduce the blood levels of sofosbuvir, which may make the medication less effective in treating hepatitis C. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Major

rifAMPin voxilaprevir

Applies to: rifampin and Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Using voxilaprevir together with rifAMPin is not recommended. Combining these medications may significantly reduce the blood levels of voxilaprevir, which may make the medication less effective in treating hepatitis C. Talk to your doctor if you have any questions or concerns. Your doctor may be able to prescribe alternatives that do not interact. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Moderate

voxilaprevir food

Applies to: Vosevi (sofosbuvir / velpatasvir / voxilaprevir)

Food may help the absorption of voxilaprevir. You should take this medication with food as directed.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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