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Drug interactions between Prilosec OTC and Prozac

Results for the following 2 drugs:
Prilosec OTC (omeprazole)
Prozac (fluoxetine)

Interactions between your drugs

There were no interactions found in our database between Prilosec OTC and Prozac - however, this does not necessarily mean no interactions exist. Always consult with your doctor or pharmacist.

Prilosec OTC

A total of 340 drugs (1991 brand and generic names) are known to interact with Prilosec OTC.


A total of 1118 drugs (6299 brand and generic names) are known to interact with Prozac.

Drug and food interactions


FLUoxetine food

Applies to: Prozac (fluoxetine)

Alcohol can increase the nervous system side effects of FLUoxetine such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with FLUoxetine. Do not use more than the recommended dose of FLUoxetine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. Talk to your doctor or pharmacist if you have any questions or concerns.

Switch to professional interaction data

Therapeutic duplication warnings

No therapeutic duplications were found for your selected drugs.

Drug Interaction Classification

The classifications below are a guideline only. The relevance of a particular drug interaction to a specific patient is difficult to determine using this tool alone given the large number of variables that may apply.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No information available.

Do not stop taking any medications without consulting your healthcare provider.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.