Drug Interactions between Priftin and tovorafenib
This report displays the potential drug interactions for the following 2 drugs:
- Priftin (rifapentine)
- tovorafenib
Interactions between your drugs
rifapentine tovorafenib
Applies to: Priftin (rifapentine) and tovorafenib
Consumer information for this interaction is not currently available.
MONITOR: Coadministration with inducers of CYP450 2C8 may decrease the plasma concentrations and pharmacologic effects of tovorafenib, which has been found in vitro to be primarily metabolized by CYP450 2C8 and aldehyde oxidase, and to a lesser extent, by the isoenzymes CYP450 3A, 2C9, and 2C19. However, data from formal clinical drug interaction studies are not available.
MANAGEMENT: Caution is advised if tovorafenib is to be used concomitantly with CYP450 2C8 inducers. Patients should be monitored for diminished therapeutic effect. Clinical and laboratory monitoring may also be considered whenever a CYP450 2C8 inducer is added to or withdrawn from therapy. Alternative therapy may need to be considered if a drug interaction is suspected.
References
- (2024) "Product Information. Ojemda (tovorafenib)." Day One Biopharmaceuticals, Inc.
Drug and food interactions
rifapentine food
Applies to: Priftin (rifapentine)
Food enhances the absorption of rifapentine and may reduce the incidence of stomach upset, nausea, and/or vomiting. However, if rifapentine is part of a combination product, the recommendations may differ. Talk to your healthcare provider if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.
Therapeutic duplication warnings
No warnings were found for your selected drugs.
Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.
See also
Drug Interaction Classification
| Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. | |
| Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. | |
| Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. | |
| No interaction information available. |
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
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