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Drug Interactions between pexidartinib and Zegerid

This report displays the potential drug interactions for the following 2 drugs:

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Interactions between your drugs

Major

omeprazole pexidartinib

Applies to: Zegerid (omeprazole / sodium bicarbonate) and pexidartinib

By reducing the acidity level in the stomach, omeprazole may interfere with the absorption of pexidartinib and reduce its effectiveness. Your doctor may be able to prescribe alternatives that do not interact or interact to a lesser extent and instruct you how to take these medicines. Talk to your doctor if you have any questions or concerns. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Moderate

sodium bicarbonate pexidartinib

Applies to: Zegerid (omeprazole / sodium bicarbonate) and pexidartinib

Talk to your doctor before using pexidartinib together with sodium bicarbonate. Sodium bicarbonate can interfere with the absorption of pexidartinib and reduce its effectiveness if they are taken too close together. In some cases, your doctor may want to prescribe alternatives that do not interact. Otherwise, you may be able to minimize the interaction by taking pexidartinib at least 2 hours before or 2 hours after sodium bicarbonate. Contact your doctor if your condition worsens during treatment with these medications. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Drug and food interactions

Major

pexidartinib food

Applies to: pexidartinib

You may experience reduced absorption of pexidartinib in the presence of food. Pexidartinib should be taken on an empty stomach at least 1 hour before or 2 hours after food. This will make it easier for your body to absorb the medication. Also, while taking pexidartinib, you should avoid grapefruits and grapefruit juice. Grapefruit and grapefruit juice can raise the levels of pexidartinib in your body and lead to potentially dangerous adverse effects. Do not increase or decrease the amount of grapefruit products in your diet without first talking to your doctor. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medications without first talking to your doctor.

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Therapeutic duplication warnings

No warnings were found for your selected drugs.

Therapeutic duplication warnings are only returned when drugs within the same group exceed the recommended therapeutic duplication maximum.

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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